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Inferences and Legal Considerations Following a Blood Collection Tube Recall.
Journal of Analytical Toxicology ( IF 2.3 ) Pub Date : 2020-05-22 , DOI: 10.1093/jat/bkaa056
Luke N Rodda 1, 2 , Sue Pearring 1 , Curt E Harper 3 , Nicholas B Tiscione 4 , Alan Wayne Jones 5
Affiliation  

In mid-2019, medical, forensic and legal communities were notified that a certain shipment of evacuated blood sampling tubes were recalled by the manufacturer. This recall order described that the preservative sodium fluoride (100 mg) and anticoagulant potassium oxalate (20 mg) were missing from a small batch of 10 mL-evacuated tubes. This gave cause for concern for possible implications in criminal justice (e.g., in drink-driving offenses), when blood-alcohol concentrations (BAC) are interpreted. In reality, the lack of an anticoagulant would have been immediately obvious during sample preparation, owing to the formation of a large clot in the tube as received. Certain impairing drugs (e.g., cocaine and 6-acetylmorphine) are unstable in blood and tend to degrade without an enzyme inhibitor, such as sodium fluoride, present. In reviewing available literature related to current practices and the stability of ethanol in stored blood samples, there does not appear to be a clear consensus regarding the amount of sodium fluoride preservative necessary, if any at all, when blood is taken from living subjects under sterile conditions for typical forensic ethanol analysis.

中文翻译:

召回采血管后的推论和法律考虑。

在2019年中,医疗,法医和法律界被告知制造商召回了一定数量的抽空采血管。该召回令描述了少量的10 mL真空管中缺少防腐剂氟化钠(100 mg)和抗凝性草酸钾(20 mg)。当解释血液中的酒精浓度(BAC)时,这引起了对刑事司法(例如,酒后驾驶犯罪)中可能影响的关注。实际上,由于在接收时在试管中形成了大的凝块,因此在样品制备过程中立即会发现抗凝剂的缺乏。某些减损药物(例如可卡因和6-乙酰吗啡)在血液中不稳定,并且在不存在酶抑制剂(例如氟化钠)的情况下易于降解。
更新日期:2020-05-22
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