Differential Effects of Saikosaponins A, B2, B4, C and D on Alcohol and Chocolate Self-Administration in Rats.,Alcohol and Alcoholism

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Differential Effects of Saikosaponins A, B2, B4, C and D on Alcohol and Chocolate Self-Administration in Rats.
Alcohol and Alcoholism ( IF 2.8 ) Pub Date : 2020-05-22 , DOI: 10.1093/alcalc/agaa049
Paola Maccioni ₁ , Irene Lorrai _{1,

2,

3} , Federica Fara ₁ , Mauro A M Carai ₄ , Gian Luigi Gessa _{1,

2} , Young-Won Chin ₅ , Jung Hwan Lee ₆ , Hak Cheol Kwon ₆ , Federico Corelli ₇ , Giancarlo Colombo ₁

Affiliation

Treatment with saikosaponin A (SSA)—an ingredient of the medicinal herb, Bupleurum falcatum—has been reported to suppress several addictive-like behaviors, including morphine, cocaine, alcohol and chocolate self-administration in male rats. The aim of this investigation was to investigate whether saikosaponins of B. falcatum other than SSA affect alcohol and chocolate self-administration in rats.

中文翻译：

柴胡皂苷 A、B2、B4、C 和 D 对大鼠酒精和巧克力自我管理的差异影响。

据报道，用柴胡皂苷 A (SSA)（一种药草柴胡的成分）进行治疗可以抑制雄性大鼠的几种成瘾行为，包括吗啡、可卡因、酒精和巧克力的自我给药。本研究的目的是调查SSA 以外的镰刀菌的柴胡皂苷是否会影响大鼠的酒精和巧克力自我给药。

更新日期：2020-06-22

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