In eukaryotes, chromatin remodeling and post-translational modifications (PTMs) shape the local chromatin landscape to establish permissive and repressive regions within the genome, orchestrating transcription, replication, and DNA repair in concert with other epigenetic mechanisms. Though cellular nutrient signaling encompasses a huge number of pathways, recent attention has turned to the hypothesis that the metabolic state of the cell is communicated to the genome through the type and concentration of metabolites in the nucleus that are cofactors for chromatin-modifying enzymes. Importantly, both epigenetic and metabolic dysregulation are hallmarks of a range of diseases, and this metabolism-chromatin axis may yield a well of new therapeutic targets. In this Perspective, we highlight emerging themes in the inter-regulation of the genome and metabolism via chromatin, including nonenzymatic histone modifications arising from chemically reactive metabolites, the expansion of PTM diversity from cofactor-promiscuous chromatin-modifying enzymes, and evidence for the existence and importance of subnucleocytoplasmic metabolite pools.

中文翻译：

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染色质是代谢产物经济中的主要消费者。

在真核生物中，染色质重塑和翻译后修饰（PTM）塑造了局部染色质景观，从而在基因组内建立了允许和抑制的区域，与其他表观遗传机制协同协调转录，复制和DNA修复。尽管细胞营养信号传导涵盖了许多途径，但最近的注意力转向了一种假设，即细胞的代谢状态通过细胞核中代谢物的类型和浓度传递给基因组，所述代谢物是染色质修饰酶的辅助因子。重要的是，表观遗传和代谢失调都是多种疾病的标志，而这种代谢－染色质轴可能会产生很多新的治疗靶标。从这个角度来看，