Abstract

Schinus polygamus (Anacardiaceae) is a shrub cultivated in Egypt for ornamental purpose. The major components of bark oil were dl-limonene (29.74%), followed by myrtenal (14.02%) and caryophyllene oxide (11.34%), while E-caryophyllene (55.86%), dl-limonene (27.71%) and β-pinene (3.54%) were predominant in the leaf oil. These isolated oils were screened for their antimicrobial activity against Staphylococcus aureus ATCC 33591, Staphylococcus aureus ATCC 29213, Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 10145, Candida albicans MTCC183 and Aspergillus niger NRRL 595, and two clinical isolates of Staphylococcus aureus. The leaf oil showed a remarkable inhibitory effect against all tested bacterial strains with minimum inhibitory concentration (MIC) range of 25 to 300 µg/mL, while the bark oil was active against Escherichia coli ATCC 25922 and Pseudomonas aeruginosa ATCC 10145 only. Furthermore, the bark and leaf oils revealed potent cytotoxic effects on HepG2 and Caco-2 cells with IC₅₀ values of 1.56 to 24.12 µg/mL.

摘要

Schinus polygamus (Anacardiaceae) 是一种在埃及种植的灌木，用于观赏。树皮油的主要成分为dl-柠檬烯（29.74%），其次是桃金娘（14.02%）和石竹烯氧化物（11.34%），E-石竹烯（55.86%）、dl-柠檬烯（27.71%）和β-蒎烯(3.54%) 在叶油中占主导地位。筛选这些分离的油对金黄色葡萄球菌ATCC 33591 、金黄色葡萄球菌ATCC 29213、大肠杆菌ATCC 25922、铜绿假单胞菌ATCC 10145、白色念珠菌MTCC183 和曲霉的抗菌活性NRRL 595 和两种金黄色葡萄球菌临床分离株。叶油对所有测试的细菌菌株显示出显着的抑制作用，最小抑制浓度 (MIC) 范围为 25 至 300 µg/mL，而树皮油仅对大肠杆菌ATCC 25922 和铜绿假单胞菌ATCC 10145有活性。此外，树皮和叶油显示出对 HepG2 和 Caco-2 细胞的有效细胞毒性作用，IC ₅₀值为 1.56 至 24.12 µg/mL。