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Investigation of antihyperalgesic and antiedematous activities of three Hieracium species
Natural Product Research ( IF 1.9 ) Pub Date : 2020-05-22 , DOI: 10.1080/14786419.2020.1768086
Violeta Milutinović 1 , Uroš Pecikoza 2 , Maja Tomić 2 , Radica Stepanović-Petrović 2 , Marjan Niketić 3 , Ljuboš Ušjak 1 , Silvana Petrović 1
Affiliation  

Abstract

Present study investigated triterpene profile, antihyperalgesic and antiedematous activities of Hieracium scheppigianum flowering aerial parts dichloromethane extract (SCH), and antihyperalgesic and antiedematous activities of previously chemically characterised polyphenol-rich H. glabratum and H. calophyllum flowering aerial parts methanol extracts (GLA and CAL, respectively). α- and β-Amyrin and their acetates, and lupeol acetate were identified and quantified in SCH by GC-FID and GC-MS. In carrageenan-induced localised inflammation model in rats, SCH and GLA (50–200 mg/kg, p.o.) produced significant and dose-dependent antihyperalgesic effect of 26.9%–56.2% (ED50=163.0 ± 26.5 mg/kg) and 25.3%–51.6% (ED50=211.6 ± 70.6 mg/kg), respectively, and CAL (200 mg/kg, p.o.) exhibited effect of 38.1%. Extracts did not significantly reduce paw edema. SCH and GLA, which demonstrated higher (over 50%) antihyperalgesic efficacy, were tested in a rotarod test (200 mg/kg, p.o.) and no alteration of motor coordination was observed. Also, acute administration of SCH and GLA in mice (2000 mg/kg, p.o.) caused neither mortality nor toxicity.



中文翻译:

三种山柰属植物的镇痛抗水肿活性研究

摘要

目前的研究调查了三萜类成分、山楂开花地上部分二氯甲烷提取物 (SCH) 的抗痛觉过敏和抗水肿活性,以及​​先前化学表征的富含多酚的H. glabratumH 的抗痛觉过敏和抗水肿活性。calophyllum开花地上部分甲醇提取物(分别为 GLA 和 CAL)。通过 GC-FID 和 GC-MS 在 SCH 中鉴定和定量α - 和β -香树脂素及其乙酸盐和羽扇豆醇乙酸酯。在角叉菜胶诱导的大鼠局部炎症模型中,SCH 和 GLA(50–200 mg/kg,po)产生 26.9%–56.2%(ED 50=163.0 ± 26.5 mg/kg) 和 25.3%–51.6% (ED 50 =211.6 ± 70.6 mg/kg) 和 CAL (200 mg/kg, po) 表现出 38.1% 的效果。提取物没有显着减轻爪水肿。SCH 和 GLA 表现出更高(超过 50%)的抗痛觉过敏功效,在旋转棒试验(200 毫克/千克,口服)中进行了测试,没有观察到运动协调的改变。此外,在小鼠中急性施用 SCH 和 GLA (2000 mg/kg, po) 既不会导致死亡也不会引起毒性。

更新日期:2020-05-22
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