Abstract

A phytochemical study of 80% ethanol extract from the aerial parts of Euphorbia helioscopia led to the isolation of three new jatrophane diterpenoids, euphoheliphanes A-C (1–3). Their structures were established on the basis of spectroscopic data (NMR, IR, UV, and MS). The isolated diterpenoids were tested in vitro for cytotoxic potentials against 6 renal cancer cell lines. As a result, compounds 1–3 exhibited some cytotoxic activities against all the tested tumor cell lines with IC₅₀ values less than 50 μM.

中文翻译：

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来自大戟属植物地上部分的细胞毒性麻风树二萜

摘要

对来自大戟属植物地上部分的 80% 乙醇提取物的植物化学研究导致分离出三种新的麻风树二萜类化合物，即大戟 AC ( 1-3 )。它们的结构是根据光谱数据（NMR、IR、UV 和 MS）确定的。在体外测试了分离的二萜对 6 种肾癌细胞系的细胞毒性潜力。因此，化合物1-3对所有测试的肿瘤细胞系均表现出一定的细胞毒活性，IC ₅₀值小于 50 μM。