Abstract

A new andirobin-type limonoid with modified furan ring, khaysenelide K (1), together with a known analogue (2), was isolated from the stem barks of Khaya senegalensis. The structure and absolute configuration of 1 were elucidated by a combination of 1D and 2D NMR, HRESIMS, and single-crystal X-ray diffraction using mirror Cu-Kα radiation. Compound 1 showed moderate NO inhibitory activity in LPS-activated RAW 264.7 macrophages with IC₅0 value of 27.74 ± 0.68 μM.

中文翻译：

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塞内加尔海藻茎皮中呋喃片段的异构化安德罗宾型柠檬苦素

摘要

具有修饰的呋喃环A新andirobin型柠檬苦素，khaysenelide K（1），与已知的类似物（一起2）中，从干树皮分离非洲楝。通过结合1D和2D NMR，HRESIMS和使用镜面Cu-Kα辐射的单晶X射线衍射，阐明了1的结构和绝对构型。化合物1在LPS激活的RAW 264.7巨噬细胞中显示出中等的NO抑制活性，IC ₅ 0值为27.74±0.68μM。