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Furan fragment isomerized andirobin-type limonoids from the stem barks of Khaya senegalensis
Journal of Asian Natural Products Research ( IF 1.3 ) Pub Date : 2020-05-22 , DOI: 10.1080/10286020.2020.1767080
Yun-Ge Bu 1 , Wen-Yan Zhang 1 , Qin-Pei Lu 1 , Jun Luo 1 , Ling-Yi Kong 1
Affiliation  

Abstract

A new andirobin-type limonoid with modified furan ring, khaysenelide K (1), together with a known analogue (2), was isolated from the stem barks of Khaya senegalensis. The structure and absolute configuration of 1 were elucidated by a combination of 1D and 2D NMR, HRESIMS, and single-crystal X-ray diffraction using mirror Cu-Kα radiation. Compound 1 showed moderate NO inhibitory activity in LPS-activated RAW 264.7 macrophages with IC50 value of 27.74 ± 0.68 μM.



中文翻译:

塞内加尔海藻茎皮中呋喃片段的异构化安德罗宾型柠檬苦素

摘要

具有修饰的呋喃环A新andirobin型柠檬苦素,khaysenelide K(1),与已知的类似物(一起2)中,从干树皮分离非洲楝。通过结合1D和2D NMR,HRESIMS和使用镜面Cu-Kα辐射的单晶X射线衍射,阐明了1的结构和绝对构型。化合物1在LPS激活的RAW 264.7巨噬细胞中显示出中等的NO抑制活性,IC 5 0值为27.74±0.68μM。

更新日期:2020-05-22
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