Introduction

The inception of nanostructured lipid carriers (NLCs) proved to be a revolutionary step toward the treatment of dermatological disorders. To uncover its true potential, it is imperative that the system be characterized and evaluated comprehensively.

Areas covered

The present review has been written to furnish an in-depth account of analytical tools and evaluation procedures under one roof. Besides discussing the challenges of topical delivery and benefits of NLCs, the paper elaborates on their physicochemical characterization. Further, in vitro evaluation of NLCs for dermatological benefits, followed by their evaluation in a hydrogel/cream base is covered. Lastly, disease-specific evaluation of NLC-based formulations is presented.

Expert opinion

The research endeavors for NLCs have largely focused on the fabrication of NLCs for different bioactives. However, scientific efforts should be aimed toward the lesser explored realm of NLCs, i.e. exploitation of analytical techniques, such as Parelectric spectroscopy, Electron Spin Resonance, and Nuclear Magnetic Resonance spectroscopy. NLCs have been proven for their potential to foster the therapeutic modalities applicable to cutaneous disorders. More attention needs to be devoted to their evaluation for disease-specific parameters. The futuristic steps must involve clinical studies, to lay the path for their commercialization.

中文翻译：

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基于纳米结构脂质载体的局部递送系统的分析工具和评估策略。

介绍

纳米结构脂质载体（NLC）的诞生被证明是迈向治疗皮肤病的革命性一步。为了发现其真正的潜力，必须对系统进行特征化和全面评估。

覆盖区域

撰写本审查报告是为了深入分析分析工具和评估程序。除了讨论局部递送的挑战和NLC的益处外，本文还详细介绍了它们的理化特性。此外，涵盖了NLC在皮肤方面的有益效果的体外评估，然后在水凝胶/乳膏基质中对其进行评估。最后，介绍了基于NLC的制剂的疾病特异性评估。

专家意见

NLC的研究工作主要集中在针对不同生物活性物质的NLC的制备上。但是，科学的努力应朝着NLC尚未探索的领域发展，即利用分析技术，例如顺电光谱，电子自旋共振和核磁共振光谱。已证明NLC具有促进适用于皮肤疾病的治疗方式的潜力。需要对它们对疾病特定参数的评估给予更多关注。未来的步骤必须涉及临床研究，以为其商业化铺平道路。