Melanoma is the deadliest form of skin cancer and one of few cancers with a growing incidence. A thorough understanding of its pathogenesis is fundamental to developing new strategies to combat mortality and morbidity. Zebrafish—due in large part to their tractable genetics, conserved pathways, and optical properties—have emerged as an excellent system to model melanoma. Zebrafish have been used to study melanoma from a single tumor initiating cell, through metastasis, remission, and finally into relapse. In this review, we examine seminal zebrafish studies that have advanced our understanding of melanoma.

中文翻译：

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从坦克到治疗：在斑马鱼中模拟黑素瘤。

黑色素瘤是最致命的皮肤癌形式，也是少数几例发病率不断上升的癌症之一。对其发病机理的透彻了解是制定新的策略来对抗死亡率和发病率的基础。斑马鱼-很大程度上是由于其易处理的遗传学，保守的途径和光学特性-已成为模拟黑素瘤的优秀系统。斑马鱼已被用于从单个肿瘤起始细胞通过转移，缓解直至最终复发来研究黑色素瘤。在这篇综述中，我们研究了斑马鱼的开创性研究，这些研究提高了我们对黑素瘤的理解。