Effect of the topology on the antibacterial activity of cationic polythioether synthesized by all‐click chemistry,Journal of Polymer Science

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Effect of the topology on the antibacterial activity of cationic polythioether synthesized by all‐click chemistry
Journal of Polymer Science ( IF 3.9 ) Pub Date : 2020-05-22 , DOI: 10.1002/pol.20200021
Yaochen Zheng ₁ , Jian Liu ₁ , Yan Guo ₁ , Qian Zhang ₁ , Xuan Gao ₁ , Zhengguo Gao ₁ , Tao He ₁ , Qingfu Ban ₁

Affiliation

Cationic compounds often serve as antibacterial materials for a wide range of applications. However, the relationship of topology−antibacterial activity has been rarely revealed. Herein, three cationic polythioethers (CPTEs) with hyperbranched topologies are well designed and facilely synthesized via an all‐click chemistry strategy (including thiol‐ene and epoxy‐amine additions). These as‐prepared CPTEs were found to exhibited outstanding antibacterial activity against Escherichia coli and Staphylococcus aureus with minimum inhibitory concentrations against E. coli of 7.3, 14.6, and 14.6 μg ml⁻¹, and against S. aureus of 14.6, 29.2, and 29.2 μg ml⁻¹, respectively. The antibacterial activity is coincident with their degree of branching (DB, their DB values of 0.81, 0.48, and 0.27), which is mainly attributed to the inherent three‐dimensional structure. The present strategy reveals the relationship of polymer topology and antibacterial activity, providing a novel possibility for designing and/or synthesis of high‐efficiency antibacterial agents.

中文翻译：

拓扑结构对全点击化学合成阳离子聚硫醚抗菌活性的影响

阳离子化合物通常用作广泛应用的抗菌材料。但是，很少揭示拓扑结构与抗菌活性之间的关系。在这里，通过全点击化学策略（包括添加硫醇和环氧胺），精心设计并轻松合成了三种具有超支化拓扑结构的阳离子聚硫醚（CPTE）。这些所制备的CPTES被发现表现出对优秀的抗菌活性的大肠杆菌和金黄色葡萄球菌与最低抑菌浓度对大肠杆菌的7.3，14.6，和14.6微克毫升^-1，以及对S的金黄色葡萄球菌14.6，29.2，和29.2微克毫升^-1，分别。抗菌活性与它们的支化度（DB，其DB值为0.81、0.48和0.27）一致，这主要归因于固有的三维结构。本策略揭示了聚合物拓扑结构与抗菌活性之间的关系，为设计和/或合成高效抗菌剂提供了新的可能性。

更新日期：2020-05-22

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