Erectile dysfunction (ED) is a common male sexual dysfunction and is closely related to many risk factors such as age, chronic diseases and mental disorder. Phosphodiesterase type 5 inhibitor (PDE5i) is recommended as the first‐line medicine in therapy, but up to 35% of patients fail to this treatment. Unfortunately, the pathogenesis of ED is still poorly understood. Hence, it has reached the state that researchers should seek for new candidate biomarkers or therapeutic targets. Recent studies have reported that noncoding RNAs (ncRNAs) such as microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) are involved in the pathogenesis process of ED, even in stem cell therapy. In this review, we aim to summarise the mechanisms and functions of identified ncRNAs that are associated with ED.

中文翻译：

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鉴定出的非编码RNA在勃起功能障碍中的作用。

勃起功能障碍（ED）是男性常见的性功能障碍，与许多危险因素（例如年龄，慢性疾病和精神障碍）密切相关。推荐使用磷酸二酯酶5型抑制剂（PDE5i）作为治疗的一线药物，但多达35％的患者未能接受该治疗。不幸的是，ED的发病机理仍知之甚少。因此，研究人员应寻求新的候选生物标志物或治疗靶点。最近的研究报道，甚至在干细胞治疗中，ED的发病过程也涉及非编码RNA（ncRNA），例如microRNA（miRNA）和长非编码RNA（lncRNA）。在这篇综述中，我们旨在总结已鉴定与ED相关的ncRNA的机制和功能。