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Comparison of the clinical efficacy of daily use of L-arginine, tadalafil and combined L-arginine with tadalafil in the treatment of elderly patients with erectile dysfunction.
Andrologia ( IF 2.1 ) Pub Date : 2020-05-22 , DOI: 10.1111/and.13640
Mohammed Abu El-Hamd 1 , Eisa Mohammed Hegazy 2
Affiliation  

This study aimed to evaluate the efficacy of the daily oral administrations of L‐arginine, tadalafil and combined L‐arginine with tadalafil in treatments of elderly patients with erectile dysfunction (ED). It was designed as a single‐blind placebo‐controlled clinical trial. It was conducted on 120 male patients aged ≥60 years old with ED. Patients were randomised classified into four groups (n  = 30 each). Oral daily use of L‐arginine (5 g), tadalafil (5 mg), combined L‐arginine (5 g) with tadalafil (5 mg) and placebo were taken for 6 weeks in each group of patients respectively. Patients were assessed before and after treatments using the Sexual Health Inventory for Men (SHIM) questionnaire and total serum testosterone. The means of Q1–5, total scores of SHIM and total testosterone, in L‐arginine, tadalafil and combined L‐arginine with tadalafil groups were significantly higher after treatments (p  = .001). Combined L‐arginine with tadalafil group had the highest SHIM scores and levels of total testosterone. This clinical trial deduced that the combined daily use of L‐arginine with tadalafil therapy for elderly male patients with ED could significantly increase the SHIM scores and levels of total testosterone in comparison to L‐arginine, or tadalafil alone.

中文翻译:

每日使用L-精氨酸,他达拉非和L-精氨酸联合他达拉非治疗老年勃起功能障碍的临床疗效比较。

这项研究旨在评估每日口服L-精氨酸,他达拉非和L-精氨酸与他达拉非联合治疗老年勃起功能障碍(ED)的疗效。它被设计为单盲安慰剂对照的临床试验。该研究针对120名年龄≥60岁的ED男性患者进行。将患者随机分为四组(n = 30个)。每组患者分别每日口服L-精氨酸(5 g),他达拉非(5 mg),L-精氨酸(5 g)与他达拉非(5 mg)和安慰剂合用。使用“男性性健康清单”(SHIM)问卷和总血清睾丸激素对治疗前后的患者进行评估。L-精氨酸,他达拉非和联合L-精氨酸与他达拉非治疗组的Q1-5平均值,SHIM和总睾丸激素总分在治疗后显着更高(p = .001)。L-精氨酸联合他达拉非组的SHIM评分和总睾丸激素水平最高。该临床试验推论,与单独使用L-精氨酸或他达拉非的男性相比,每天使用L-精氨酸和他达拉非治疗的老年男性ED可以显着提高SHIM评分和总睾丸激素水平。
更新日期:2020-07-08
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