Arthrocen, an avocado-soy unsaponifiable agent, improves acetic acid-induced colitis in rat by inhibition of NF-kB signaling pathway.,Journal of Food Biochemistry

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Arthrocen, an avocado-soy unsaponifiable agent, improves acetic acid-induced colitis in rat by inhibition of NF-kB signaling pathway.
Journal of Food Biochemistry ( IF 3.5 ) Pub Date : 2020-05-22 , DOI: 10.1111/jfbc.13244
Ramin Goudarzi ₁ , Alireza Partoazar _{2,

3} , Faiza Mumtaz _{2,

3} , Hasan Yousefi-Manesh ₃ , Alireza Abdollahi ₄ , Ahmadreza Dehpour _{2,

3} , Amir Rashidian _{2,

3}

Affiliation

The goal of the current study was to evaluate the anti‐inflammatory effect of Arthrocen against acetic acid‐induced colitis in rats. Acute inflammation was produced through intrarectal administration of 2 ml diluted acetic acid (4%) solution. All interventions were carried out for 5 days after colitis induction. Arthrocen was administered orally at doses of 30, 60, and 120 mg kg⁻¹ day⁻¹. Then, macroscopic and microscopic studies were performed. Myeloperoxidase (MPO) activity and tumor necrosis factor‐α (TNF‐α) activity were measured by biochemical and ELISA methods, respectively. Immunohistochemistry was done to investigate the expression of pNF‐κB. The results of this study demonstrated that Arthrocen reduced macroscopic and microscopic damage compared to the acetic acid group. Furthermore, Arthrocen decreased the activity of MPO and TNF‐α as well as the protein expression of pNF‐kB in rat colon tissue. The results of the current study revealed the anti‐inflammatory activity of Arthrocen in acetic acid mediated colon inflammation through suppressing the NF‐κB pathway.

中文翻译：

牛油果大豆不皂化物Arthrocen通过抑制NF-kB信号通路改善乙酸诱发的大鼠结肠炎。

本研究的目的是评估关节炎对大鼠乙酸诱发的结肠炎的抗炎作用。通过直肠内注射2 ml稀乙酸（4％）溶液产生急性炎症。结肠炎诱发后，所有干预均进行5天。关节炎剂量为30、60和120 mg kg ^-1 天^-1口服。然后，进行了宏观和微观研究。用生化和ELISA方法分别测定髓过氧化物酶（MPO）活性和肿瘤坏死因子-α（TNF-α）活性。进行了免疫组织化学研究pNF-κB的表达。这项研究的结果表明，与乙酸组相比，节肢动物减少了宏观和微观损伤。此外，Arthrocen降低了大鼠结肠组织中MPO和TNF-α的活性以及pNF-kB的蛋白表达。目前的研究结果显示，关节炎素通过抑制NF-κB途径对乙酸介导的结肠炎症具有抗炎作用。

更新日期：2020-05-22

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