Hydrophobic Interaction Chromatography in 2 D Liquid Chromatography Characterization of Lignosulfonates.,ChemSusChem

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Hydrophobic Interaction Chromatography in 2 D Liquid Chromatography Characterization of Lignosulfonates.
ChemSusChem ( IF 7.5 ) Pub Date : 2020-05-22 , DOI: 10.1002/cssc.202000849
Oliver Musl ₁ , Irina Sulaeva ₁ , Markus Bacher ₁ , A Kai Mahler ₂ , Thomas Rosenau ₁ , Antje Potthast ₁

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Lignosulfonates are bulk‐scale byproducts of industrial sulfite pulping. Their amphiphilic character plays a central role in their successful application in large‐scale materials production. As an inherent feature of the chemical structure, this amphiphilic character poses a major analytical challenge. In this study, the amphiphilic behavior of an industrial lignosulfonate was investigated by hydrophobic interaction chromatography (HIC). This technique exploits hydrophobic regions present on the surface of lignosulfonates. Extensive characterization of the obtained fractions from preparative HIC, in terms of elemental composition, functional‐group content, chemical structure, and molecular weight distribution, revealed a detailed picture of the chemical composition distribution. The charge‐to‐size ratio, that is, differences in the degree of sulfonation, was the dominant factor governing separation in HIC. A combination of HIC with size exclusion chromatography showed good orthogonality of separation and demonstrated the power of this 2 D liquid chromatography approach for an in‐depth characterization, in general, and amphiphilicity, in particular.

中文翻译：

木质素磺酸盐二维液相色谱表征中的疏水相互作用色谱。

木质素磺酸盐是工业亚硫酸盐制浆的大规模副产品。它们的两亲特性在大规模材料生产中的成功应用中发挥着核心作用。作为化学结构的固有特征，这种两亲性特征提出了重大的分析挑战。在这项研究中，通过疏水相互作用色谱（HIC）研究了工业木质素磺酸盐的两亲行为。该技术利用木质素磺酸盐表面上存在的疏水区域。对从制备型 HIC 中获得的馏分在元素组成、官能团含量、化学结构和分子量分布方面进行了广泛的表征，揭示了化学成分分布的详细图片。电荷尺寸比，即磺化程度的差异，是控制 HIC 分离的主要因素。HIC 与尺寸排阻色谱的组合显示出良好的分离正交性，并证明了这种二维液相色谱方法在一般情况下和特别是两亲性方面进行深入表征的能力。

更新日期：2020-05-22

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