Objective

To compare the effects of two different doses of butorphanol combined with detomidine administered intravenously (IV) on quality of sedation, degree of ataxia and anaesthetic induction in horses.

Study design

Randomized, blinded, clinical study.

Animals

A total of 40 client-owned healthy warmblood horses scheduled for elective surgery under general anaesthesia.

Methods

Horses were randomly allocated to be administered 8 μg kg^–1 detomidine IV plus either 20 or 50 μg kg^–1 butorphanol IV, with the principal investigator blinded to group allocation. Head height was measured before drug injection and 2 minutes thereafter. Data were compared using unpaired t test. Horses were filmed and scored using Simple Descriptive Scales for sedation (2 and 15 minutes after IV injection), ataxia (at walk, immediately after the 2 minute time point) and quality of swing-door induction following diazepam and ketamine administration. Data are shown as median (and range where appropriate). Scores were compared using chi-square tests (p < 0.05).

Results

There were 14 and 17 horses in high-dose (HD) and low-dose (LD) groups respectively. Data from nine horses were excluded. Mean head height reduction did not differ between groups (p = 0.86), nor did sedation scores at 2 minutes (median = 3 in both groups; p = 0.09) or 15 minutes (median = 2 in both groups; p = 0.63). There was no significant difference in the requirement for additional detomidine (p = 0.73) or in induction quality between groups (p = 0.99), but initial ataxia was significantly greater in the HD group 2 (1–3) versus 2.5 (1–3) in the LD group (p = 0.017).

Conclusions and clinical relevance:

In healthy warmblood horses, simultaneous administration of 50 rather than 20 μg kg^–1 butorphanol with 8 μg kg^–1 detomidine does not provide greater sedation or affect induction, but it causes more pronounced ataxia shortly after IV injection.

中文翻译：

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两剂丁啡尼诺与地托米丁对健康温血马的静脉前药治疗的临床效果。

目的

为了比较两种不同剂量的布托啡诺联合地托米定静脉内（IV）对马的镇静质量，共济失调程度和麻醉诱导的影响。

学习规划

随机，盲法临床研究。

动物

共有40例客户拥有的健康温血马计划在全身麻醉下进行择期手术。

方法

马被随机分配到待施用8微克千克^-1托咪定IV加20或50微克千克^-1布托啡诺IV，用盲法组分配的主要研究者。在注射药物之前和之后的2分钟测量头高。使用不成对的t检验比较数据。使用简单描述性量表对马进行镇静（IV注射后2和15分钟），共济失调（在步行，2分钟时间点后立即）和共安定和氯胺酮治疗后的开门诱导质量，并对马进行评分。数据显示为中位数（以及适当的范围）。使用卡方检验比较得分（p <0.05）。

结果

高剂量（HD）和低剂量（LD）组分别有14匹和17匹马。排除了来自九匹马的数据。各组的平均头部高度降低没有差异（p  = 0.86），在2分钟（两组中位数= 3；p  = 0.09）或15分钟（两组中位数= 2；p  = 0.63）时的镇静分数也没有差异。有用于附加地托咪定（要求无显著差异p  = 0.73），或在基团之间感应质量（p  = 0.99），但初始共济失调是HD组2（1-3）在显著更大与2.5（1-3 ）在LD组（p  = 0.017）。

结论与临床意义：

在健康的温血马，50而不是20同时给药微克千克^-1布托啡诺，8微克千克^-1托咪定不提供更大的镇静或影响诱导，但它IV注射后不久导致更显着的共济失调。