The aim of this research is to perform an analysis of the epineurial and endoneurial blood vessels in relation to aging. The research is conducted on samples of the human sciatic nerve of 12 case (age from 27 to 89). The histological sections are stained by streptavidin-biotin method of detecting the presence of Type IV collagen. After morphometric analysis the following stereological parameters have been calculated: the number of blood vessels per unit of area, the volume density of the blood vessels and the surface density of the blood vessels of the epineurium and endoneurium. An additional diameter measurement is performed for the endoneural blood vessels. In order to perform a more detailed analysis, the cases were classified into three age groups, the first (27–48 years), the second (49–70 years) and, the third (over 70 years). The bivariate correlation analysis showed that the number of blood vessels of the endoneurium, their volume and surface densities in relation to age produced a statistically significant positive correlation. One Way ANOVA test demonstrated a statistically significant increase in the number of endoneurial blood vessels in the age group III when compared the age group I and, in addition, it showed a significant decrease in the diameter of the age group II when compared to the age group I. Paired t – test shows a statistically significant higher number of endoneurial blood vessels in relation to the epineurial, namely, in the age group III. The volume and surface density of the epineurial blood vessels is significantly higher than the endoneurial in both the I and II age group. Age brings about significant changes of the endoneurial vascular network of the sciatic nerve due to the increase in density of the endoneurial blood vessels, their volume and surface densities. Consequently, in the cases older than 70 years, the number of endoneurial blood vessels significantly exceeds the number of epineurial blood vessels.

这项研究的目的是对与衰老有关的肾上腺和神经内膜血管进行分析。该研究是针对12例（27至89岁）的人类坐骨神经样本进行的。用链霉亲和素-生物素方法对组织切片进行染色，以检测IV型胶原蛋白的存在。经过形态分析后，已计算出以下立体参数：单位面积的血管数量，血管的体积密度以及神经外膜和神经内膜的血管表面密度。对神经内膜血管进行额外的直径测量。为了进行更详细的分析，将病例分为三个年龄组，第一组（27-48岁），第二组（49-70岁），第三​​组（70岁以上）。二元相关分析表明，与年龄相关的神经内膜血管数量，其体积和表面密度产生了统计学上显着的正相关。单向ANOVA测试表明，与I组相比，III组的神经内膜血管数量具有统计学意义的增加，此外，与I组相比，II组的直径明显减小配对t检验显示，与肾上腺有关，即在III岁年龄组，神经内膜血管的数量具有统计学意义。I和II年龄组的肾小管血管的体积和表面密度均显着高于神经内膜。由于神经内膜血管密度，体积和表面密度的增加，年龄使坐骨神经的神经内膜血管网络发生重大变化。因此，在超过70岁的情况下，神经内膜血管的数量明显超过了神经膜上血管的数量。