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Antimicrobial and wound healing activities of certain Sudanese medicinal plants.
Saudi Journal of Biological Sciences Pub Date : 2020-05-22 , DOI: 10.1016/j.sjbs.2020.05.017
Ehssan H Moglad 1, 2 , Abubaker M Hamad 3, 4 , Farhat Fatima 1 , Vidya Devanathadesikan Seshadri 5 , Mamuna Naz 5
Affiliation  

The emergence of drug-resistant organisms have been increasing globally; therefore, it is a burning need to find an alternative drug to get rid of the diseases caused by resistant strains. This study aims to evaluate the antimicrobial and wound healing activities of Loranthus acacia, Cassia obtusifolia and Cymbopogon proximus plants. All the plants were collected and extracted — by maceration method. Antimicrobial activities determined using standard ATCC strain for Gram-positive bacteria (Bacillus subtilis, Bacillus crew, Methicillin-resistant Staphylococcus aureus, Staphylococcus aureus) and Gram-negative bacteria (Shigella sonnnei, Salmonella Typhimurium, Salmonella typhi, Klebsiella pnuemoniae, Escherichia coli and Pseudomonas aeruginosa) following agar well diffusion method. Plants extracts were prepared as gel and investigated for in vivo wound healing activities in rats. Histological studies were performed on animals’ skin. The results showed that all tested plants have various antimicrobial and wound healing activities. Out of these plants, L. acacia exhibited the best result; it revealed a significant result for antimicrobial activities counter to all Gram-positive, Gram-negative bacteria and wound healing activities in comparing with the reference drug. Thus, it is essential to consider L. acacia as a prospective source in progress in the synthesis of a new antimicrobial drug for the treatment of infectious diseases.



中文翻译:

某些苏丹药用植物的抗菌和伤口愈合活性。

全球耐药菌的出现正在增加;因此,迫切需要找到一种替代药物来摆脱由耐药菌株引起的疾病。这项研究的目的是评估金合欢,决明子Cymbopogon proximus植物的抗菌和伤口愈合活性通过浸渍法收集和提取所有植物。使用标准ATCC菌株对革兰氏阳性菌(枯草芽孢杆菌,水生芽孢杆菌,耐甲氧西林金黄色葡萄球菌金黄色葡萄球菌)和革兰氏阴性菌(志贺氏志贺氏菌)测定抗菌活性鼠伤寒沙门氏菌伤寒沙门氏菌克雷伯氏菌pnuemoniae大肠杆菌绿脓杆菌)以下琼脂孔扩散法。将植物提取物制成凝胶,并研究其在大鼠体内的伤口愈合活性。在动物皮肤上进行了组织学研究。结果表明,所有测试的植物均具有多种抗菌和伤口愈合活性。在这些植物中,金合欢表现最好;与参考药物相比,它显示出对抗所有革兰氏阳性,革兰氏阴性细菌的抗菌活性和伤口愈合活性的重要结果。因此,至关重要的是,将金合欢菌作为合成治疗感染性疾病的新抗菌药物的潜在来源。

更新日期:2020-05-22
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