Background

Though the relationship between chronic rhinosinusitis (CRS) and lower airway diseases is well recognized, the impact of CRS on bronchial wall structure has not been elucidated. Here, we evaluated the bronchial wall structure of CRS patients with or without diagnosed airway diseases by three-dimensional computed tomography (3D-CT).

Methods

Subjects who underwent both chest CT and sinus CT within a year were recruited from consecutive medical records. CRS was defined as a Lund-Mackay score (LMS) of over 5 points. Airway dimensions were measured using validated software. Standard blood tests and pulmonary function tests were performed, and their correlation with airway thickness was examined.

Results

One-hundred-seventy-two patients were recruited (93 CRS subjects and 79 non-CRS subjects). The bronchial walls of CRS subjects were significantly thicker than those of non-CRS subjects. CRS and asthma were related to bronchial wall thickening by multivariate linear regression analysis adjusted for age, smoking status, and chest symptoms. In addition, LMS was significantly correlated with bronchial wall thickening.

Conclusion

Airway walls in CRS subjects were thicker than those in non-CRS subjects and associated with the severity of CRS. These data indicate strong relationship between upper and lower airways regardless of chest symptoms or diagnosed airway diseases.

中文翻译：

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支气管壁增厚与慢性鼻-鼻窦炎的严重程度有关。

背景

尽管慢性鼻-鼻窦炎（CRS）和下呼吸道疾病之间的关系已得到公认，但尚未阐明CRS对支气管壁结构的影响。在这里，我们通过三维计算机断层扫描（3D-CT）评估了有或没有气道疾病的CRS患者的支气管壁结构。

方法

从连续的医疗记录中招募了一年内同时进行了胸部CT和鼻窦CT检查的受试者。CRS被定义为Lund-Mackay得分（LMS）超过5分。使用经过验证的软件测量气道尺寸。进行标准血液检查和肺功能检查，并检查它们与气道厚度的相关性。

结果

招募了132名患者（93名CRS受试者和79名非CRS受试者）。CRS受试者的支气管壁明显比非CRS受试者的支气管壁厚。通过对年龄，吸烟状况和胸部症状进行校正的多元线性回归分析，CRS和哮喘与支气管壁增厚有关。此外，LMS与支气管壁增厚显着相关。

结论

CRS受试者的气道壁比非CRS受试者的气道壁厚，并且与CRS的严重程度有关。这些数据表明，无论胸部症状或诊断出的气道疾病如何，上，下气道之间都存在很强的关系。