Silene species are known for their use in traditional medicine in treating several diseases. To the authors' knowledge there is no report on the chemical composition of S. odontopetala. Therefore, the phytochemical investigation of the methanol extract of S. odontopetala was carried out, leading to the isolation of six undescribed oleanane-type glycosides along with the known saponin azukisaponin IV. Their structures were elucidated by the analysis of 1D and 2D-NMR experiments, along with mass spectrometry analysis. The cytotoxic activity of oleanane-type saponins was evaluated against a small panel of cancer cell lines, including PC-3 (prostate carcinoma cells), MCF-7 (breast cancer cells), A549 (alveolar basal carcinoma cells), and HeLa (cervical carcinoma cells). Furthermore, the activity of isolated compounds against a normal cell line HEK-293, used for assessing their cytotoxicity, was evaluated.

中文翻译：

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来自 Silene odontopetala 的三萜糖苷

Silene 物种因其在传统医学中用于治疗多种疾病而闻名。据作者所知，没有关于 S. odontopetala 化学成分的报告。因此，对 S. odontopetala 的甲醇提取物进行了植物化学研究，导致分离出六种未描述的齐墩果型糖苷以及已知的皂苷 azukisaponin IV。通过 1D 和 2D-​​NMR 实验分析以及质谱分析阐明了它们的结构。齐墩果型皂苷对一小部分癌细胞系的细胞毒活性进行了评估，包括 PC-3（前列腺癌细胞）、MCF-7（乳腺癌细胞）、A549（肺泡基底癌细胞）和 HeLa（宫颈癌细胞）。癌细胞）。此外，