The human gut microbiota is the most important active part of the intestinal micro-ecosystem. Lifestyle modification, drug intake and nutrition have an impact on the composition of the gut microbiota and its metabolites. This review focuses on the effects of changes in the gut microbiota as well as the important metabolite Trimethylamine-N-oxide (TMAO). Furthermore, relevant therapeutic options to target the human microbiome in patients with cardiovascular disease are presented.

中文翻译：

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在心血管疾病的预防和治疗中针对人类微生物组及其代谢产物TMAO。

人肠道微生物群是肠道微生态系统中最重要的活性部分。生活方式的改变，药物的摄入和营养都会影响肠道菌群及其代谢产物的组成。这篇综述着重于肠道菌群变化以及重要的代谢产物三甲胺-N-氧化物（TMAO）的影响。此外，提出了针对心血管疾病患者的人类微生物组的相关治疗选择。