It is crucial to reveal the variability between patients with epilepsy and healthy subjects to elucidate the underpinnings of the disease pathology. Herein, we assessed the inter-subject variability between patients with temporal lobe epilepsy (TLE) and healthy subjects in terms of estimating the functional connectivity using resting-state functional magnetic resonance (rs-fMRI) scans. According to inter-subject variability results between healthy and TLE population, the latter showed more variability mainly in frontoparietal control, default mode, dorsal/ventral attention, visual and somatomotor networks in line with the broad seizure onset and propagation pathway. As a result of 17-Network parcellation, a significant attenuation is observed in functional connectivity, mostly in bilateral frontoparietal control, somatomotor, default mode and ventral attention networks associated with the functional impairment in attention, long/short term memory, executive functioning. The results are in favor of the argument that the functional disruption in TLE spreads throughout the cortex beyond the temporal lobe with an implication of greater diversity in the TLE population.

揭示癫痫患者与健康受试者之间的差异对阐明疾病病理学的基础至关重要。本文中，我们根据静息状态功能磁共振（rs-fMRI）扫描评估功能连通性，评估了颞叶癫痫（TLE）患者与健康受试者之间的受试者间变异性。根据健康人群和TLE人群之间的受试者间变异性结果，后者显示出更大的变异性，主要是在前绝经控制，默认模式，背/腹注意力，视觉和躯体运动网络方面，与广泛的癫痫发作和传播途径一致。17-网络分割的结果是，在功能连接中观察到了明显的衰减，主要是在双边额叶控制，躯体运动，默认模式和腹侧注意网络与注意功能，长期/短期记忆，执行功能相关。该结果支持这样一种论点，即TLE的功能破坏分布在整个颞叶以外的整个皮层，这意味着TLE种群具有更大的多样性。