Serine, a non-essential amino acid, has attracted clinical attention because of potential benefit in certain metabolic and neurological disorders. Despite the therapeutic potential, little is known about the pharmacokinetics of l-serine metabolism in humans. Here we present pharmacokinetic data at the time of treatment initiation as well as plasma serine levels during dose escalation from a single individual taking oral l-serine as part of a treatment regimen. Our results show that plasma serine levels rise and fall rapidly after oral l-serine intake, suggesting that the optimal dosing for oral l-serine supplementation is at least three times per day.

丝氨酸是一种非必需氨基酸，因其对某些代谢和神经系统疾病的潜在益处而引起了临床关注。尽管具有治疗潜力，但人们对L-丝氨酸代谢在人体中的药代动力学知之甚少。在这里，我们提供了一个服用口服L-丝氨酸作为治疗方案一部分的个体在治疗开始时的药代动力学数据以及剂量递增期间的血浆丝氨酸水平。我们的结果表明，口服L-丝氨酸摄入后，血浆丝氨酸水平迅速上升和下降，这表明口服L-丝氨酸补充剂的最佳剂量是每天至少 3 次。