Abstract Transdermal drug delivery offers several advantages over other conventional modalities for drug administration, such as injections and oral administrations. It can be activated by exogenous energy sources, including electric and magnetic fields, or by light and ultrasound (US). Ultrasound can induce the degradation and deformation of a polymeric matrix, thus promoting the release of entrapped drugs and the topical administration through the skin. Our aim is to create a wearable patch composed of an ultrasound-responsive polymeric system encapsulating specific drugs, which are released on demand by the application of ultrasound. In this work, we investigate the effect of ultrasound on square poly(lactic-co-glycolic acid) (PLGA) microparticles loaded with curcumin (CURC), called curcumin-microplates (CURC-μPLs), realized using a top-down fabrication process. Using Finite Element Method (FEM) simulations, we identified the resonant frequencies and the mode shape of the μPLs. Guided by this simulation, we applied ultrasound stimulus at frequency of 1 MHz, close to the first mechanical resonance frequency of the microplates, leading to a 200% increase in CURC release rate after 30 min of ultrasonic treatment. This approach can be generalized to any ultrasound-sensitive matrix filled with specific drugs and with piezoelectric compliant transducers embedded in the smart patch for generating ultrasonic waves.

中文翻译：

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PLGA 微板的超声诱导变形，用于按指令释放药物

摘要 与其他常规给药方式（例如注射和口服给药）相比，经皮给药具有多种优势。它可以被外源性能源激活，包括电场和磁场，或光和超声波（美国）。超声波可以诱导聚合物基质的降解和变形，从而促进包埋药物的释放和通过皮肤局部给药。我们的目标是创造一种可穿戴贴片，由超声响应聚合物系统组成，其中封装了特定药物，通过超声应用按需释放。在这项工作中，我们研究了超声波对装载姜黄素 (CURC) 的方形聚乳酸-乙醇酸共聚物 (PLGA) 微粒的影响，称为姜黄素微孔板 (CURC-μPLs)，使用自上而下的制造工艺实现。使用有限元方法 (FEM) 模拟，我们确定了 μPL 的谐振频率和模式形状。在此模拟的指导下，我们以 1 MHz 的频率施加超声刺激，接近微孔板的第一机械共振频率，导致超声处理 30 分钟后 CURC 释放率增加 200%。这种方法可以推广到任何填充有特定药物和嵌入智能贴片中的压电顺应换能器以产生超声波的超声敏感基质。接近微孔板的第一个机械共振频率，导致超声处理 30 分钟后 CURC 释放率增加 200%。这种方法可以推广到任何填充有特定药物和嵌入智能贴片中的压电顺应换能器以产生超声波的超声敏感基质。接近微孔板的第一个机械共振频率，导致超声处理 30 分钟后 CURC 释放率增加 200%。这种方法可以推广到任何填充有特定药物和嵌入智能贴片中的压电顺应换能器以产生超声波的超声敏感基质。