The association between plasma HMGB1 and sRAGE and clinical outcome in intracerebral hemorrhage,Journal of Neuroimmunology

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The association between plasma HMGB1 and sRAGE and clinical outcome in intracerebral hemorrhage
Journal of Neuroimmunology ( IF 2.9 ) Pub Date : 2020-08-01 , DOI: 10.1016/j.jneuroim.2020.577266
Chunyan Lei ₁ , Jia Geng ₁ , Lianmei Zhong ₁

Affiliation

High-mobility group box 1 (HMGB1) and advanced glycation end-products (RAGE) are potential mediators of inflammation. We investigate the association between levels of HMGB1 and soluble RAGE (sRAGE) following intracerebral hemorrhage (ICH) and the severity of ICH. There was a significant trend towards higher poor functional outcome rate with increasing HMGB1 and sRAGE tercile. The correlation analysis indicated that the levels of HMGB1and sRAGE were positively correlated with hematoma volume. The receiver operating curve (ROC) was 0.718 for HMGB1 and 0.631 for sRAGE to poor functional outcome. HMGB1 and sRAGE quantification provides more accurate prognostic information after ICH.

中文翻译：

血浆HMGB1和sRAGE与脑出血临床结局的关系

高迁移率族框 1 (HMGB1) 和晚期糖基化终产物 (RAGE) 是炎症的潜在介质。我们调查了脑出血 (ICH) 后 HMGB1 和可溶性 RAGE (sRAGE) 水平与 ICH 严重程度之间的关联。随着 HMGB1 和 sRAGE tercile 的增加，出现更高的不良功能结果率的显着趋势。相关分析表明HMGB1和sRAGE水平与血肿体积呈正相关。HMGB1 的受试者工作曲线 (ROC) 为 0.718，sRAGE 为 0.631，导致功能结果不佳。HMGB1 和 sRAGE 量化提供了更准确的 ICH 后预后信息。

更新日期：2020-08-01

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