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Porogen Effect on Structural and Physical Properties of β-TCP Scaffolds for Bone Tissue Regeneration
IRBM ( IF 4.8 ) Pub Date : 2020-05-22 , DOI: 10.1016/j.irbm.2020.05.007
C. Ruiz-Aguilar , U. Olivares-Pinto , R.A.L. Drew , E.A. Aguilar-Reyes , I. Alfonso

Scaffolds for bone tissue applications have been an outstanding alternative to repair and regenerate bone tissue defects caused by traumas or illness. There are many methods available to fabricate porous scaffold such as solvent casting, gas bubble, phase separation, electrospinning, particle-leaching, among others. The particle-leaching technique has shown advantages in bone tissue regeneration applications, the main benefit of this technique is related to the porogen particle size and the porogen content in the manufacture of scaffolds. Tricalcium phosphate is one calcium phosphate that presented appropriated characteristic to be used for bone tissue engineering due to the chemical properties similar to the human bones. Scaffolds of tricalcium phosphate β phase were made using sugar particles. The porogen was varied in amounts of 50, 60 and 70 wt.% of two commercial sugars with the remainder of the composition made up of tricalcium phosphate powders. The pore sizes in all the scaffolds were in the range of 90 to 600 μm with an irregular pore morphology and the porosity was in the range of 63 to 77%.



中文翻译:

致孔剂对用于骨组织再生的 β-TCP 支架的结构和物理特性的影响

用于骨组织应用的支架已成为修复和再生由外伤或疾病引起的骨组织缺损的杰出替代品。有许多方法可用于制造多孔支架,例如溶剂浇铸、气泡、相分离、静电纺丝、颗粒浸出等。颗粒浸出技术在骨组织再生应用中显示出优势,该技术的主要好处与支架制造中的致孔剂粒径和致孔剂含量有关。磷酸三钙是一种磷酸钙,由于其化学性质与人体骨骼相似,因此具有适合用于骨组织工程的特性。磷酸三钙β支架相是使用糖颗粒制成的。致孔剂以50、60和70重量%的两种市售糖的量变化,组合物的其余部分由磷酸三钙粉末组成。所有支架的孔径在 90 至 600 μm 范围内,孔隙形态不规则,孔隙率在 63% 至 77% 范围内。

更新日期:2020-05-22
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