当前位置: X-MOL 学术Int. J. Infec. Des. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
A 16-year retrospective study on fungal prevalence and diversity in patients with Cystic Fibrosis- Candida dubliniensis was associated with a decline in lung function
International Journal of Infectious Diseases ( IF 4.8 ) Pub Date : 2020-07-01 , DOI: 10.1016/j.ijid.2020.05.063
Mahasin Al Shakirchi 1 , Lena Klingspor 2 , Peter Bergman 3 , Lena Hjelte 1 , Isabelle de Monestrol 1
Affiliation  

OBJECTIVES To study the prevalence of fungal species in CF patients over a 16 years period, as well as the impact of C. albicans, C. dubliniensis and A. fumigatus on lung function. METHODS Observational single-center cohort study (2000-2015) including 133 CF patients (ages 6-66 years). Linear mixed models with autoregressive covariance matrix were used. RESULTS C. albicans was the most common fungus (prevalence 62%) followed by A. fumigatus (22%) and C. dubliniensis (11%). In the initial year of detection, there was no impact of C. albicans, C. dubliniensis or A. fumigatus on lung function. However, one and two years after detection of C. dubliniensis a reduction in ppFEV1 with 3.8%, p=0.022, (year 1) and with 4.1%, p=0.017 (year 2) compared to CF patients without these findings, was observed. Furthermore, patients with positive cultures for any of these fungal species for three consecutive years exhibited a decline in lung function (C. dubliniensis, 7.6% reduction in ppFEV1, p=0.001; A. fumigatus, 4.9%, p=0.007; C. albicans, 2.6%, p=0.014). The results were adjusted for age, CFTR genotype, chronic and intermittent P. aeruginosa colonization and numbers of intravenous antibiotic treatments per year. Persistence of C. dubliniensis for three consecutive years was correlated positively to age and ESR (both p=0.001). CONCLUSIONS CF patients who were cultured positive for C. dubliniensis, C. albicans or A. fumigatus in sputum exhibited a decline in ppFEV1 over time. The effect was most pronounced for C. dubliniensis.

中文翻译:

一项关于囊性纤维化患者的真菌流行率和多样性的 16 年回顾性研究 - 都柏林念珠菌与肺功能下降有关

目的 研究 16 年间 CF 患者真菌种类的流行情况,以及白色念珠菌、都柏林念珠菌和烟曲霉对肺功能的影响。方法 观察性单中心队列研究(2000-2015)包括 133 名 CF 患者(年龄 6-66 岁)。使用具有自回归协方差矩阵的线性混合模型。结果白色念珠菌是最常见的真菌(流行率为 62%),其次是烟曲霉(22%)和都柏林念珠菌(11%)。在检测的最初一年,白色念珠菌、都柏林念珠菌或烟曲霉对肺功能没有影响。然而,在检测到 C. dubliniensis 一年和两年后,观察到与没有这些发现的 CF 患者相比,ppFEV1 降低了 3.8%,p=0.022(第 1 年)和 4.1%,p=0.017(第 2 年) . 此外,连续三年对任何这些真菌物种进行阳性培养的患者表现出肺功能下降(C. dubliniensis,ppFEV1 降低 7.6%,p=0.001;A. fumigatus,4.9%,p=0.007;C. albicans, 2.6%,p=0.014)。结果根据年龄、CFTR 基因型、慢性和间歇性铜绿假单胞菌定植以及每年静脉注射抗生素治疗的次数进行了调整。C. dubliniensis 连续三年的持久性与年龄和 ESR 呈正相关(均 p=0.001)。结论 CF 患者的痰培养为 C. dubliniensis、C. albicans 或 A. fumigatus 呈阳性,随着时间的推移,ppFEV1 呈下降趋势。效果对于 C. dubliniensis 最为显着。烟曲霉,4.9%,p=0.007;白色念珠菌,2.6%,p=0.014)。结果根据年龄、CFTR 基因型、慢性和间歇性铜绿假单胞菌定植以及每年静脉注射抗生素治疗次数进行了调整。C. dubliniensis 连续三年的持久性与年龄和 ESR 呈正相关(均 p=0.001)。结论 CF 患者的痰培养为 C. dubliniensis、C. albicans 或 A. fumigatus 呈阳性,随着时间的推移,ppFEV1 呈下降趋势。效果对于 C. dubliniensis 最为显着。烟曲霉,4.9%,p=0.007;白色念珠菌,2.6%,p=0.014)。结果根据年龄、CFTR 基因型、慢性和间歇性铜绿假单胞菌定植以及每年静脉注射抗生素治疗的次数进行了调整。C. dubliniensis 连续三年的持久性与年龄和 ESR 呈正相关(均 p=0.001)。结论 CF 患者的痰培养为 C. dubliniensis、C. albicans 或 A. fumigatus 呈阳性,随着时间的推移,ppFEV1 呈下降趋势。效果对于 C. dubliniensis 最为显着。dubliniensis 连续三年与年龄和 ESR 呈正相关(均 p=0.001)。结论 CF 患者的痰培养为 C. dubliniensis、C. albicans 或 A. fumigatus 呈阳性,随着时间的推移,ppFEV1 呈下降趋势。效果对于 C. dubliniensis 最为显着。dubliniensis 连续三年与年龄和 ESR 呈正相关(均 p=0.001)。结论 CF 患者的痰培养为 C. dubliniensis、C. albicans 或 A. fumigatus 呈阳性,随着时间的推移,ppFEV1 呈下降趋势。效果对于 C. dubliniensis 最为显着。
更新日期:2020-07-01
down
wechat
bug