This study reviews the relevant epidemiological studies associating cutaneous melanoma and breast carcinomas and provides an overview of the possible genetic, biological and bias factors that underpin this relationship. Standardised incidence ratio (SIR) for primary cutaneous melanoma after breast carcinoma ranged from 1.16 to 5.13 and ranged from 1.03 to 4.10 for primary breast carcinoma after cutaneous melanoma. Epidemiological studies highlight age, gender and use of radiotherapy and chemotherapy as potential risk factors for second primary cancers (SPCs). Mutations in BRCA2, CDKN2A, CDK4 and BAP1 may partly underlie any SPC association. The impact of socio-cultural factors and surveillance bias may be attributed to the findings of SPC partially or entirely. In conclusion, this study has highlighted the association between breast carcinoma and melanoma and identified various factors for further research and the optimised management of patients with both cancers.

这项研究回顾了与皮肤黑色素瘤和乳腺癌相关的相关流行病学研究，并概述了支持这种关系的可能的遗传，生物学和偏倚因素。乳腺癌后原发性皮肤黑素瘤的标准发生率（SIR）为1.16至5.13，皮肤癌后的原发性乳腺癌的标准发生率为1.03至4.10。流行病学研究强调年龄，性别以及放疗和化疗的使用是第二原发癌（SPC）的潜在危险因素。BRCA2，CDKN2A，CDK4和BAP1中的突变可能部分是任何SPC关联的基础。社会文化因素和监视偏见的影响可能部分或全部归因于SPC的发现。结论，