Strategic designing catanionic system that leads to vesicle formation is advantageous if one of the components is hydrotropic ‘drug’. Vesicles are size-selective filters that offer passive diffusion of small molecules including drugs and are the best alternatives to liposomes and niosomes. Drug molecules can be carried irrespective to their polarity in vesicles cage/bilayer, which makes them a convenient drug delivery vehicle. Herein we have investigated concentration/composition dependent catanionic vesicles through synergistic interactions between cationic gemini surfactants (GS) and hydrotropic drug, diclofenac sodium (DS). Variables studied to get shape and size-dependent catanionic vesicles includes: alkyl chain length of GS and concentration of DS. We used spectroscopic probes to study the microscopic interactions, dynamic light scattering (DLS) to determine the size and transmission electron microscopy (TEM) and small angle neutron scattering (SANS) to determine the exact shape and size of the vesicles. This work could be of interest in the field of drug delivery as the possible new age nano-carriers.

如果组分之一是水溶性“药物”，则导致囊泡形成的策略性设计阳离子体系是有利的。囊泡是尺寸选择的过滤器，可提供包括药物在内的小分子的被动扩散，是脂质体和脂质体的最佳替代物。可以在小泡笼/双层中携带药物分子而不论其极性如何，这使它们成为方便的药物递送载体。在本文中，我们通过阳离子双子表面活性剂（GS）与水溶药物双氯芬酸钠（DS）之间的协同相互作用研究了浓度/组成依赖的阳离子小泡。为获得形状和尺寸相关的阳离子小泡而研究的变量包括：GS的烷基链长和DS的浓度。我们使用了光谱探针来研究微观相互作用，动态光散射（DLS）确定大小和透射电子显微镜（TEM）以及小角中子散射（SANS）确定小泡的确切形状和大小。作为可能的新时代纳米载体，这项工作可能在药物输送领域引起关注。