OBJECTIVE To explore the diagnostic accuracy of the split-hand index (SHI) for amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA) using sonographic assessment of muscle thickness. METHODS We performed a prospective sonographic assessment of hand muscle thickness in 59 controls, 87 patients with ALS, and 33 patients with SMA. We determined the diagnostic accuracy of SHI for differentiating patients with ALS and SMA from controls. RESULTS Patients with ALS and SMA had significantly lower muscle thickness and SHI values compared with controls. SHI showed excellent diagnostic accuracy for differentiating ALS from controls, and good diagnostic accuracy for differentiating SMA from controls. CONCLUSIONS SHI determined by sonographic measurement of hand muscle thickness seems to be a promising tool for the diagnosis of ALS and may be added easily when performing neuromuscular ultrasound. SIGNIFICANCE SHI determined by sonographic measurement of hand muscle thickness can differentiate between healthy subjects and patients with ALS and SMA.

中文翻译：

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运动神经元疾病中的分手现象：肌肉厚度的超声评估

目的 使用超声评估肌肉厚度，探讨分手指数 (SHI) 对肌萎缩侧索硬化 (ALS) 和脊髓性肌萎缩症 (SMA) 的诊断准确性。方法 我们对 59 名对照组、87 名 ALS 患者和 33 名 SMA 患者的手部肌肉厚度进行了前瞻性超声评估。我们确定了 SHI 用于区分 ALS 和 SMA 患者与对照组的诊断准确性。结果 与对照组相比，ALS 和 SMA 患者的肌肉厚度和 SHI 值显着降低。SHI 在区分 ALS 与对照方面表现出出色的诊断准确性，在区分 SMA 与对照方面表现出良好的诊断准确性。结论 通过超声测量手部肌肉厚度确定的 SHI 似乎是诊断 ALS 的有前途的工具，并且在进行神经肌肉超声检查时很容易添加。意义 通过超声测量手部肌肉厚度确定的 SHI 可以区分健康受试者和 ALS 和 SMA 患者。