OBJECTIVES The aim of the present study was to determine the relationships of drooling with motor symptoms and nigrostriatal neuron loss in drug-naïve patients with Parkinson's disease (PD). We therefore examined the relationships of drooling with motor symptoms and striatal dopamine transporter (DAT) binding measured by [123-Iodine]-fluoropropyl-2beta-carbomethoxy-3beta-(4-iodophenylnortropane) dopamine transporter single-photon emission computed tomography(123I-FP-CIT SPECT). PATIENTS AND METHODS Thirty-five untreated PD patients (14 men and 21 women with a mean age of 71.9 ± 7.2 years) were included in this study. The patients were divided into a drooler group and non-drooler group. They underwent clinical assessments and 123I-FP-CIT SPECT imaging. Motor symptoms were assessed using Unified Parkinson's Disease Rating Scale (UPDRS). RESULTS The results showed that UPDRS motor score (p = 0.002) and akinetic-rigid score (p = 0.008) were higher and that striatal DAT availability (p = 0.03) was lower in the drooler group than in the non-drooler group. However, tremor score, age, and duration of PD showed no significant differences between the drooler group and non-drooler group. CONCLUSIONS Drooling in untreated PD is related to an increase in motor symptoms (especially bradykinesia and axial symptoms) and to reduction of striatal DAT availability.

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初治帕金森病患者流口水与运动症状及多巴胺转运体成像的关系

目的 本研究的目的是确定未接受药物治疗的帕金森病 (PD) 患者流口水与运动症状和黑质纹状体神经元丢失之间的关系。因此，我们检查了流口水与运动症状和纹状体多巴胺转运蛋白 (DAT) 结合的关系，这些结合通过 [123-碘]-氟丙基-2β-碳甲氧基-3β-(4-碘苯基去甲托烷) 多巴胺转运蛋白单光子发射计算机断层扫描 (123I- FP-CIT SPECT）。患者和方法 本研究包括 35 名未经治疗的 PD 患者（14 名男性和 21 名女性，平均年龄为 71.9 ± 7.2 岁）。将患者分为流口水组和不流口水组。他们接受了临床评估和 123I-FP-CIT SPECT 成像。使用统一帕金森病评定量表 (UPDRS) 评估运动症状。结果 结果表明，与非流口水组相比，流口水组的 UPDRS 运动评分 (p = 0.002) 和运动障碍刚性评分 (p = 0.008) 更高，纹状体 DAT 可用性 (p = 0.03) 较低。然而，震颤评分、年龄和 PD 持续时间在流口水组和非流口水组之间没有显着差异。结论 未经治疗的 PD 患者流口水与运动症状（尤其是运动迟缓和轴性症状）的增加以及纹状体 DAT 可用性的降低有关。流口水组和非流口水组之间的PD持续时间没有显着差异。结论 未经治疗的 PD 患者流口水与运动症状（尤其是运动迟缓和轴性症状）的增加以及纹状体 DAT 可用性的降低有关。流口水组和非流口水组之间的PD持续时间没有显着差异。结论 未经治疗的 PD 患者流口水与运动症状（尤其是运动迟缓和轴性症状）的增加以及纹状体 DAT 可用性的降低有关。