d-Serine, a long-term undetected enantiomer of serine, is now showing its potential as a biomarker for kidney diseases. The intra-body dynamics of d-serine, currently defined by blood levels and urinary excretion dynamics, are useful for a comprehensive assessment of kidney function and disease activity. Thus, widespread adoption of d-serine as a biomarker can resolve the long-standing clinical challenge of the early detection and prognostic prediction of kidney diseases. Accuracy and reliability of the measurements are particularly important because these measurements will affect treatment decisions and thus impact the patient's emotional state and quality of life. Accordingly, this review focuses on current clinical challenges in kidney diseases and the potential for monitoring of d-serine to overcome these issues, and discuss the requirements of accurate quantification.

d-丝氨酸是一种长期未发现的丝氨酸对映体，目前正显示出其作为肾脏疾病生物标志物的潜力。目前由血液水平和尿排泄动力学定义的d-丝氨酸的体内动力学可用于全面评估肾功能和疾病活动。因此，d的广泛采用丝氨酸作为生物标志物可以解决长期存在的对肾脏疾病的早期发现和预后预测的临床挑战。测量的准确性和可靠性尤为重要，因为这些测量将影响治疗决策，从而影响患者的情绪状态和生活质量。因此，本综述着眼于当前肾脏疾病的临床挑战以及监测d-丝氨酸克服这些问题的潜力，并讨论了准确定量的要求。