The important role of histone deacetylases in modulating vascular physiology and arteriosclerosis,Atherosclerosis

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The important role of histone deacetylases in modulating vascular physiology and arteriosclerosis
Atherosclerosis ( IF 4.9 ) Pub Date : 2020-06-01 , DOI: 10.1016/j.atherosclerosis.2020.04.020
Ting C Zhao ₁ , Zhengke Wang ₂ , Tina Y Zhao ₃

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Cardiovascular diseases are the leading cause of deaths in the world. Endothelial dysfunction followed by inflammation of the vessel wall leads to atherosclerotic lesion formation that causes ischemic heart and myocardial hypertrophy, which ultimately progress into cardiac dysfunction and failure. Histone deacetylases (HDACs) have been recognized to play crucial roles in cardiovascular disease, particularly in the epigenetic regulation of gene transcription in response to a variety of stresses. The unique nature of HDAC regulation includes that HDACs form a complex co-regulatory network with other transcription factors, deacetylate histones and non-histone proteins to facilitate the regulatory mechanism of the vascular system. The selective HDAC inhibitors are considered as the most promising target in cardiovascular disease, especially for preventing cardiac hypertrophy. In this review, we discuss our present knowledge of the cellular and molecular basis of HDACs in mediating the biological function of vascular cells and related pharmacologic interventions in vascular disease.

中文翻译：

组蛋白去乙酰化酶在调节血管生理和动脉硬化中的重要作用

心血管疾病是世界上主要的死亡原因。内皮功能障碍和血管壁炎症导致动脉粥样硬化病变形成，导致缺血性心脏和心肌肥大，最终发展为心脏功能障碍和衰竭。组蛋白去乙酰化酶 (HDAC) 已被公认为在心血管疾病中起着至关重要的作用，特别是在响应各种压力的基因转录的表观遗传调控中。HDAC 调节的独特性质包括 HDAC 与其他转录因子、脱乙酰组蛋白和非组蛋白蛋白形成复杂的共调节网络，以促进血管系统的调节机制。选择性 HDAC 抑制剂被认为是心血管疾病中最有希望的靶点，尤其是预防心脏肥大。在这篇综述中，我们讨论了我们目前对 HDAC 介导血管细胞生物学功能的细胞和分子基础的了解，以及血管疾病的相关药物干预。

更新日期：2020-06-01

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