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Diabetic retinopathy and its association with low glomerular filtration rate: a cross-sectional analysis of diabetes patients of community clinics across India
International Journal of Diabetes in Developing Countries ( IF 0.7 ) Pub Date : 2020-05-22 , DOI: 10.1007/s13410-019-00779-2
Kalpana Dash , , Aftab Ahmed , Sambit Das , Balaji Jaganmohan , Surekha Tippisetty , Vamsi Krishna Kolukula , Krishna G. Seshadri

Aims To determine the prevalence of diabetic retinopathy (DR) in patients with T2DM having low estimated glomerular filtration rate (eGFR). Methods A cross-sectional retrospective data analysis of T2DM patients’ records who were screened for DR across Apollo Sugar Clinics from June 2016 to December 2016. DR was diagnosed through fundus examination; patients having eGFR values were grouped into eGFR < 60 and eGFR ≥ 60 mg/ml/1.73 m 2 . Appropriate statistical tests were applied to identify the association of eGFR and DR, and significance was set at 2-tailed p ≤ 0.05. Results A total of 1547 T2DM patients were screened; mean (SD) age was 56.7 (10.0) years. Among them, data of 443 patients with eGFR were included in the analysis. Mean eGFR was 91.2 mg/ml/1.73 m 2 ; 12.5% patients had eGFR ≤ 60 mg/ml/1.73 m 2 and 87.5% had ≥ 60 mg/ml/1.73 m 2 . DR was observed in 79 (17.8%) patients; it was higher in males (62%) than in females (38%). Further, the proportion of patients with DR was significantly higher in patients with eGFR ≤ 60 mg/ml/1.73 m 2 compared with that in patients with eGFR ≥ 60 mg/ml/1.73 m 2 (38% vs. 15%; p < 0.001). Conclusion Association of DR with low eGFR in patients with T2DM may suggest presence of diabetes kidney disease in a community, thus reaffirming the significance of DR screening in community diabetes practices.

中文翻译:

糖尿病视网膜病变及其与低肾小球滤过率的关系:对印度社区诊所糖尿病患者的横断面分析

目的 确定具有低估计肾小球滤过率 (eGFR) 的 T2DM 患者糖尿病视网膜病变 (DR) 的患病率。方法 对 2016 年 6 月至 2016 年 12 月在 Apollo Sugar 诊所进行 DR 筛查的 T2DM 患者记录进行横断面回顾性数据分析。具有 eGFR 值的患者分为 eGFR < 60 和 eGFR ≥ 60 mg/ml/1.73 m 2 。应用适当的统计检验来确定 eGFR 和 DR 的关联,显着性设定为 2 尾 p ≤ 0.05。结果共筛查了1547名T2DM患者;平均 (SD) 年龄为 56.7 (10.0) 岁。其中,443例eGFR患者的数据被纳入分析。平均 eGFR 为 91.2 mg/ml/1.73 m 2 ;12.5% 的患者 eGFR ≤ 60 mg/ml/1.73 m 2 ,87.5% ≥ 60 mg/ml/1.73 m 2 。在 79 名 (17.8%) 患者中观察到 DR;男性(62%)高于女性(38%)。此外,与eGFR ≥ 60 mg/ml/1.73 m 2 的患者相比,eGFR ≤ 60 mg/ml/1.73 m 2 患者的DR患者比例显着更高(38% vs. 15%;p < 0.001)。结论 T2DM 患者 DR 与低 eGFR 的关联可能表明社区中存在糖尿病肾病,从而重申 DR 筛查在社区糖尿病实践中的重要性。
更新日期:2020-05-22
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