Clinical course of COVID-19 in patients with pre-existing decompensated cirrhosis: initial report from China.,Hepatology International

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Clinical course of COVID-19 in patients with pre-existing decompensated cirrhosis: initial report from China.
Hepatology International ( IF 5.9 ) Pub Date : 2020-05-22 , DOI: 10.1007/s12072-020-10051-z
Xiaolong Qi ₁ , Jitao Wang ₁ , Xinyu Li ₂ , Zhengyan Wang ₃ , Yanna Liu ₁ , Hua Yang ₄ , Xiaodan Li ₅ , Jindong Shi ₆ , Huihua Xiang ₇ , Tao Liu ₅ , Norifumi Kawada ₈ , Hitoshi Maruyama ₉ , Zicheng Jiang ₁₀ , Fengmei Wang ₁₁ , Tetsuo Takehara ₁₂ , Don C Rockey ₁₃ , Shiv Kumar Sarin ₁₄ ,

Affiliation

CHESS (Chinese Portal Hypertension Diagnosis and Monitoring Study Group) Center, Institute of Portal Hypertension, The First Hospital of Lanzhou University, Lanzhou, 730000, Gansu, China.
Department of Infectious Disease, Shanghai Fifth People's Hospital of Fudan University, Shanghai, China.
Departments of Respiratory Medicine, Suizhou Hospital, Hubei University of Medicine, Suizhou, Hubei, China.
Departments of Respiratory Medicine, Minda Hospital Affiliated to Hubei University for Nationalities, Enshi, Hubei, China.
Department of Infectious Disease, The Central Hospital of Enshi Tujia And Miao Autonomous Prefecture, Enshi, Hubei, China.
Department of Respiratory Medicine, Shanghai Fifth People's Hospital of Fudan University, Shanghai, China.
Department of Radiology, Minda Hospital Affiliated to Hubei University for Nationalities, Enshi, Hubei, China.
Department of Hepatology, Graduate School of Medicine, Osaka City University, Osaka, Japan.
Department of Gastroenterology, Juntendo University, Tokyo, Japan.
Department of Infectious Disease, Ankang Central Hospital, Ankang, China.
Department of Gastroenterology and Hepatology, Tianjin Second People's Hospital, Tianjin, China.
Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Osaka, Japan.
Division of Gastroenterology and Hepatology, Medical University South Carolina, Charleston, SC, USA.
Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India.

Background

The clinical characteristics and disease course in COVID-19 patients with pre-existing decompensated cirrhosis has not been described so far.

Methods

In this case series, we report three patients with confirmed COVID-19 and pre-existing decompensated cirrhosis from three hospitals in Hubei, the epicenter of the outbreak in China.

Result

Patient 1 was a 53-year-old man with hepatitis B virus-related cirrhosis, portal hypertension, and ascites. Though receiving intensive support, he died of irreversible multiple organ dysfunction syndrome 48 days after the onset of the illness. Patient 2 was a 75-year-old woman with a history of schistosomiasis-related cirrhosis, portal hypertension, and ascites. Her family members requested that invasive rescue measures not be undertaken, and she died of acute respiratory distress syndrome 40 days after presenting with COVID-19 infection. Patient 3 was an 87-year-old man with alcohol-related cirrhosis, portal hypertension, and esophageal variceal hemorrhage. He was discharged from the hospital 29 days after illness onset.