BACKGROUND Preterm birth (PTB) is a major adverse pregnancy outcome and largely contributes to increasing neonatal and maternal mortality. Genetic and environmental factors may play an important role in the development of PTB. Numerous studies have shown that immune genes related to the immune system, such as IL-6, IL-10, and TNFα, are associated with the occurrence of PTB. OBJECTIVE We examined genetic associations between IL-6 rs1800796, IL-10 rs1800872, and TNFα rs1800630 polymorphisms and PTB in Korean women. METHODS In this study, 115 PTB patients and 147 controls were analyzed. The genotyping of three SNPs was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). RESULTS Our result showed that the rs1800872 polymorphism was significantly associated with the development of PTB in genotype frequency (odds ratio (OR) 1.71, 95% confidence interval (CI) 1.01-2.90, p = 0.046). We also found a significant association in an analysis of combined genotypes (rs1800796 CC, rs1800872 CA, and rs1800630 CA) (OR 7.43, 95% CI 2.06-26.84, p = 0.001). In a correlation analysis, rs1800630 A allele was significantly related with the increased birth weight (g) within PTB patients (p = 0.005). CONCLUSION Our results imply possible relationships between the rs1800796, rs1800872, and rs1800630 polymorphisms and the development of PTB.

中文翻译：

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IL-6，IL-10和TNFα基因多态性与韩国女性早产之间的关联。

背景技术早产（PTB）是主要的不良妊娠结局，并且在很大程度上有助于增加新生儿和产妇的死亡率。遗传和环境因素可能在PTB的发展中起重要作用。大量研究表明，与免疫系统相关的免疫基因，例如IL-6，IL-10和TNFα与PTB的发生有关。目的我们研究了韩国女性IL-6 rs1800796，IL-10 rs1800872和TNFαrs1800630多态性与PTB之间的遗传关联。方法在本研究中，分析了115名PTB患者和147名对照。通过聚合酶链反应-限制性片段长度多态性（PCR-RFLP）对三个SNP进行基因分型。结果我们的结果表明，rs1800872多态性与基因型频率下PTB的发展显着相关（优势比（OR）1.71，95％置信区间（CI）1.01-2.90，p = 0.046）。在对组合基因型（rs1800796 CC，rs1800872 CA和rs1800630 CA）的分析中，我们还发现了显着关联（OR 7.43，95％CI 2.06-26.84，p = 0.001）。在相关分析中，rs1800630 A等位基因与PTB患者出生体重增加（g）显着相关（p = 0.005）。结论我们的结果暗示rs1800796，rs1800872和rs1800630多态性与PTB的发展之间可能存在关联。和rs1800630 CA）（OR 7.43，95％CI 2.06-26.84，p = 0.001）。在相关分析中，rs1800630 A等位基因与PTB患者出生体重增加（g）显着相关（p = 0.005）。结论我们的结果暗示rs1800796，rs1800872和rs1800630多态性与PTB的发展之间可能存在关联。和rs1800630 CA）（OR 7.43，95％CI 2.06-26.84，p = 0.001）。在相关分析中，rs1800630 A等位基因与PTB患者出生体重增加（g）显着相关（p = 0.005）。结论我们的结果暗示rs1800796，rs1800872和rs1800630多态性与PTB的发展之间可能存在关联。