Osteoarthritis is characterized by lubrication failure of the articular cartilage and severe inflammation of the joint capsule. Lubricating mesoporous silica nanoparticles (MSNs) have been developed for the treatment of osteoarthritis based on enhanced lubrication and local drug delivery. However, MSNs are difficult to degrade in vivo in a short time, resulting in potential toxic effect due to bioaccumulation. In this study, biodegradable MSNs (bMSNs) were prepared through an oil-water biphase stratification method, and modified with poly(2-methacryloyloxyethyl phosphocholine) (PMPC) to synthesize lubricating drug-loaded nanoparticles (bMSNs-NH₂@PMPC) by photopolymerization. The in vitro degradation test demonstrated that the bMSNs and bMSNs-NH₂@PMPC almost degraded within 7 days. The tribiological test showed that the lubrication property of the bMSNs-NH₂@PMPC was greatly improved, with a reduction of 50% in the friction coefficient (COF) compared with the bMSNs. It was attributed to hydration lubrication mechanism by which a tenacious hydration layer is formed surrounding the zwitterionic headgroups (N⁺(CH₃)₃ and PO₄⁻) in PMPC polyelectrolyte polymer. Additionally, the bMSNs-NH₂@PMPC maintained excellent lubrication property under degradation and achieved sustained drug release behavior compared with the bMSNs. In summary, the biodegradable bMSNs-NH₂@PMPC developed in this study with the properties of enhanced lubrication and drug delivery may be a promising approach for osteoarthritis therapy.

骨关节炎的特征在于关节软骨的润滑失败和关节囊的严重炎症。基于增强的润滑和局部药物输送，已经开发了润滑介孔二氧化硅纳米颗粒（MSN）用于治疗骨关节炎。但是，MSN难以在短时间内在体内降解，由于生物蓄积，导致潜在的毒性作用。在这项研究中，通过油-水双相分层法制备可生物降解的MSNs（bMSNs），并用聚（2-甲基丙烯酰氧基乙基磷酸胆碱）（PMPC）进行改性，以通过光聚合反应合成负载药物的纳米颗粒（bMSNs-NH ₂ @PMPC）。 。体外降解试验表明，bMSNs和bMSNs-NH ₂@PMPC在7天内几乎降级了。摩擦学测试表明，bMSNs-NH ₂ @PMPC的润滑性能大大提高，与bMSNs相比，摩擦系数（COF）降低了50％。它归因于由一个坚韧水化层的周围形成所述两性离子头部基团水合润滑机构（N ⁺（CH ₃）₃和PO ₄ ^- ）的PMPC聚电解质聚合物。此外，与bMSNs相比，bMSNs-NH ₂ @PMPC在降解下保持了优异的润滑性能，并实现了持续的药物释放性能。总之，可生物降解的bMSNs-NH ₂在这项研究中开发的具有增强润滑性和药物输送特性的@PMPC可能是骨关节炎治疗的一种有前途的方法。