This systematic review and meta-analysis aim to evaluate the association of wheat germ interventions and metabolic markers. An electronic search was performed by mid-May 2019 in the PubMed, Google Scholar, and Web of Science databases. Quality was evaluated using the risk of bias assessment tools. Thirty-three randomized controlled trials (RCTs) were identified, among which ten were suitable and systematically reviewed based on biomarkers (cholesterol, triglycerides, glucose, and oxidative stress). Three biomarkers in five eligible studies were investigated by meta-analysis. Total cholesterol showed non-significant results (p = 0.98), with standard mean difference (SMD) of − 0.01 (95% confidence interval; − 0.17, 0.16). The SMD was − 0.06 (95% CI − 0.41, 0.29, n = 4) for triglycerides and − 0.09 (95% CI − 0.62, 0.45, n = 2) for glucose. No biomarkers showed heterogeneity (0%). This review revealed non-significant association between wheat germ interventions and metabolic markers. Sensitive analysis with high-quality RCTs may be worth trying.

这项系统综述和荟萃分析旨在评估小麦胚芽干预措施与代谢标志物的关联。2019 年 5 月中旬在 PubMed、Google Scholar 和 Web of Science 数据库中进行了电子检索。使用偏倚风险评估工具评估质量。确定了 33 项随机对照试验 (RCT)，其中 10 项是合适的，并根据生物标志物（胆固醇、甘油三酯、葡萄糖和氧化应激）进行了系统评价。通过荟萃分析对五项符合条件的研究中的三种生物标志物进行了调查。总胆固醇显示不显着的结果（p = 0.98)，标准均差 (SMD) 为 − 0.01（95% 置信区间；− 0.17、0.16）。甘油三酯的 SMD 为 − 0.06 (95% CI − 0.41, 0.29, n = 4)，葡萄糖的 SMD 为 − 0.09 (95% CI − 0.62, 0.45, n = 2)。没有生物标志物表现出异质性（0%）。该综述揭示了小麦胚芽干预与代谢标志物之间不存在显着关联。高质量随机对照试验的敏感性分析可能值得尝试。