Although prior studies have reported that patients with anaplastic thyroid carcinoma (ATC) with a focal anaplastic component may have a prolonged survival compared to other ATC patients, the outcome data are limited. We evaluated a cohort of ATC resected between 2003 and 2018. Tumor slides were reviewed to confirm the diagnosis and to identify cases with a minor ATC component (defined as comprising < 10% of the tumor). We evaluated the clinical outcome of these patients compared to that of all other cohort patients (characterized as having conventional ATC). Our cohort was composed of 24 cases of ATC that underwent resection, including 8 (33%) with a minor ATC component. Tumors with a minor ATC component were predominantly associated with papillary thyroid carcinoma. For patients with tumors with a minor ATC component, the 1-year and 2-year survival rates and median survival for patients who died of disease were 88%, 43%, and 17 months (range 6–73 months), respectively. In comparison, for patients with conventional ATC, the 1-year and 2-year survival rates and median survival for patients who died of disease were 56%, 44%, and 7 months (range 2–26 months), respectively. There was no difference in 1- and 2-year survival or overall survival by Kaplan-Meier analysis for patients with tumors with a minor ATC component and those with conventional ATC. In conclusion, the difference in overall survival between ATC groups in our cohort was not significant; however, this could be due to the small cohort size or due to characteristics of our group with a minor ATC component; that is, no tumors in this group were limited to the thyroid (stage IVA), resectability with negative margins was infrequent, and 38% of this group had distant metastases at diagnosis (stage IVC).

中文翻译：

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伴有少量间变性成分的间变性甲状腺癌的组织病理学特征和临床结果。

尽管先前的研究已经报道，具有局灶性间变性成分的间变性甲状腺癌（ATC）患者与其他ATC患者相比可能具有更长的生存期，但结局数据有限。我们评估了2003年至2018年间切除的一组ATC。对肿瘤切片进行了回顾，以确认诊断并鉴定出具有较小ATC成分（定义为占肿瘤的10％）的病例。我们评估了这些患者与所有其他队列患者（表征为具有常规ATC）相比的临床结果。我们的队列由24例行切除术的ATC组成，其中8例（33％）伴有较小的ATC成分。ATC成分较少的肿瘤主要与甲状腺乳头状癌有关。对于ATC成分较少的肿瘤患者，死于疾病的患者的1年和2年生存率和中位生存期分别为88个月，43％和17个月（6-73个月）。相比之下，对于具有常规ATC的患者，死于疾病的患者的1年和2年生存率以及中位生存率分别为56％，44％和7个月（2至26个月）。通过Kaplan-Meier分析，具有较小ATC成分的肿瘤患者和具有常规ATC的肿瘤患者的1年和2年生存率或总体生存率没有差异。总之，在我们的队列中，ATC组之间的总体生存率差异不显着。但是，这可能是由于队列规模较小或由于我们的小组的ATC成分较少的特征所致；也就是说，该组中没有肿瘤局限于甲状腺（IVA分期），