Aim and Objective: Myocardial infarction, cerebral infarction, and other diseases caused by vascular obstruction have always jeopardized human life and health. Several reports indicate that Rhei Radix et Rhizoma has a good clinical effect in the prevention and treatment of cardiovascular diseases. Owing to the complexity of herbal medicine, the pharmacodynamic mechanism of Rhei Radix et Rhizoma is still unclear. The objectives of this study were to explore the two-way adjustment mechanism of Rhei Radix et Rhizoma and provide a new solution for the prevention and treatment of cardiovascular disease.

Materials and Methods: This study used data mining, reverse pharmacophore matching, network construction, GO and KEGG Analysis, and molecular docking to investigate the two-way adjustment mechanism of Rhei Radix et Rhizoma. The methods used were based on systems pharmacology and big data analysis technology.

Results: The results suggest that Rhei Radix et Rhizoma uses a two-way adjustment of activating blood circulation, as well as blood coagulation in the prevention and treatment of cardiovascular diseases. The components involved in activating blood circulation are mainly anthraquinone components. The corresponding targets are NOS2, NOS3, CALM1, and the corresponding pathways are calcium signaling pathway, VEGF signaling pathway, platelet activation, and the PI3K-Akt signaling pathway. For blood coagulation, the components are mainly tannin components; the corresponding targets are F2, F10, ELANE, and the corresponding pathways are the neuroactive ligand-receptor interaction, complement and coagulation cascades.

Conclusion: This study indicated that Rhei Radix et Rhizoma exerts the two-way adjustment of activating blood circulation and blood coagulation in the prevention and treatment of cardiovascular diseases. It can make up for the side effects of the existing blood circulation drugs for cardiovascular disease, only activating blood circulation, and the uncontrollable large-area bleeding due to the long-term use of the drugs. This study provides a material basis for the development of new blood-activating drugs based on natural medicine.

目的和目的：心肌梗塞，脑梗塞和其他由血管阻塞引起的疾病一直危及人类的生命和健康。一些报道表明，Rhei Radix et Rhizoma在预防和治疗心血管疾病方面具有良好的临床效果。由于草药的复杂性，Rhei Radix et Rhizoma的药效机理仍不清楚。本研究的目的是探索Rhei Radix et Rhizoma的双向调节机制，并为心血管疾病的预防和治疗提供新的解决方案。

材料与方法：本研究使用数据挖掘，反向药效团匹配，网络构建，GO和KEGG分析以及分子对接研究了Rhei Radix et Rhizoma的双向调节机制。使用的方法基于系统药理学和大数据分析技术。

结果：结果表明，Rhei Radix et Rhizoma使用了双向调节激活血液循环以及凝血功能来预防和治疗心血管疾病。激活血液循环的成分主要是蒽醌成分。相应的靶标是NOS2，NOS3，CALM1，相应的途径是钙信号通路，VEGF信号通路，血小板活化和PI3K-Akt信号通路。对于凝血来说，这些成分主要是单宁成分。相应的靶标是F2，F10，ELANE，相应的途径是神经活性配体-受体相互作用，补体和凝血级联反应。

结论：本研究表明，Rhei Radix et Rhizoma在预防和治疗心血管疾病方面具有激活血液循环和凝血功能的双向调节作用。它可以弥补现有的用于心血管疾病的血液循环药物的副作用，仅能激活血液循环，以及由于长期使用该药物而无法控制的大面积出血。该研究为开发基于天然药物的新型血液活化药物提供了物质基础。