The cadmium and lead binding capacities and antioxidant activities of Lactobacillus plantarum and Pichia kudriavzevii were evaluated in vitro and in vivo. Lactic acid bacteria and yeasts obtained from fermenting cassava mash and maize slurry were screened for tolerance to cadmium and lead at 500–1050 mg ml⁻¹ screened for probiotic potentials and antioxidant activities such as 2,2-diphenyl-1-picrylhydrazyl and ferric reducing antioxidant properties. The in vivo studies were carried out in male Wistar rats. The strains identified as Lactobacillus plantarum ML05 and Pichia kudriavzevii FY05 demonstrated the best probiotic potentials and antioxidant activities. Alterations in antioxidant capacities were positive in the treatment groups. The histopathology displayed positive changes in the renal tubules and glomeruli, hypertrophy, with normal capsular spaces without inflammation in the kidney, while the liver sinusoids appear normal in the rats administered with L. plantarum ML05 and P. kudriavzevii FY05 while the infected and not treated showed cell necrosis induced by toxicities. Our results provided new evidence that Lactobacillus plantarum and Pichia kudriavzevii have different biological actions on the heavy metals binding capacities and antioxidant activities in experimental animals. This study suggests that these microorganisms can be considered dietary therapeutics against cadmium and lead toxicities.

体外和体内评价了植物乳杆菌和库氏毕赤酵母的镉和铅结合能力以及抗氧化活性。筛选从木薯ma和玉米浆发酵得到的乳酸菌和酵母对镉和铅的耐受性，筛选500-1050 mg ml ^-1的益生菌潜力和抗氧化活性，例如2,2-二苯基-1-吡啶并肼和还原铁抗氧化性能。在雄性Wistar大鼠中进行了体内研究。鉴定为植物乳杆菌ML05和库氏毕赤酵母的菌株05财年证明了最佳的益生菌潜力和抗氧化活性。抗氧化剂能力的变化在治疗组中是阳性的。组织病理学显示肾小管和肾小球呈阳性变化，肥大，具有正常的荚膜空间，肾脏无炎症，而给予植物乳杆菌ML05和库德里阿维兹病毒FY05的大鼠中肝窦呈正常状态，而受感染且未治疗可见由毒性引起的细胞坏死。我们的结果为植物乳杆菌和库氏毕赤酵母提供了新的证据。对实验动物中重金属的结合能力和抗氧化活性具有不同的生物学作用。这项研究表明，这些微生物可被视为抗镉和铅中毒的饮食疗法。