Shang et al. (2016. J. Cell Biol.https://doi.org/10.1083/jcb.201603081) reported that activation of lysosomal TRPA1 channels led to intracellular calcium transients and CGRP release from DRG neurons. We argue that both findings are more likely due to influx of insufficiently buffered extracellular calcium rather than lysosomal release.

中文翻译：

---

DRG 神经元中 TRPA1 依赖性钙瞬变和 CGRP 释放需要细胞外钙

尚等人。(2016. J. Cell Biol.https://doi.org/10.1083/jcb.201603081) 报道，溶酶体 TRPA1 通道的激活导致细胞内钙瞬变和 DRG 神经元释放 CGRP。我们认为，这两种发现更有可能是由于缓冲不足的细胞外钙的流入而不是溶酶体释放所致。