Background: Recent studies have proposed that clinical and immunological differences exist between mono- and poly-sensitized subjects with allergic diseases, and poly-sensitization was related to multimorbidity of allergic diseases among children and adolescents. Objective: We compared the clinical characteristics and multimorbidity of allergic diseases between adult rhinitis patients mono- and poly-sensitized to common aeroallergens using a retrospective cross-sectional study for tertiary care subjects. Methods: The medical records of 1,615 patients who were clinically diagnosed with rhinitis by an otolaryngologist and evaluated with skin prick tests were reviewed. The severity of the rhinitis symptoms, comorbidities (asthma, conjunctivitis, and eczema), family history of allergic diseases, and the results of skin prick tests were evaluated. Results: There were 392 patients with mono-sensitized rhinitis (mono-sR), 325 with poly-sensitized rhinitis (poly-sR), and 898 with non-sensitized rhinitis (non-sR). Comorbid conjunctivitis and eczema were most common in poly-sR, followed by mono-sR, and least common in non-sR patients. The age at onset of rhinitis was clearly different between adult patients with non-sR and mono-/poly-sR, but not between patients with mono-sR and poly-sR. However, the age at onset of rhinitis was much younger in non-sR and mono-sR patients with conjunctivitis or eczema than those without such comorbidities. Conclusion: Thefrequency of comorbid conjunctivitis and eczema in adult rhinitis patients differed by a quantitative trait of immunoglobulin E sensitization. Depending on the multimorbidity of allergic diseases, onset age of rhinitis seems to be different in adult rhinitis patients.
Int Arch Allergy Immunol

中文翻译：

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在非敏感性鼻炎和单/多敏感性鼻炎中，成人鼻炎的多发病率和发病年龄的异质性：一项回顾性横断面研究。

背景：最近的研究表明，单敏和多敏过敏性受试者之间存在临床和免疫学差异，多敏与儿童和青少年过敏性疾病的多发病率有关。目的：我们通过回顾性横断面研究，对三级护理对象进行了比较，他们对成年鼻炎患者对普通空气过敏原单敏感和多敏感的变应性疾病的临床特征和多发病率进行了比较。方法：回顾了由耳鼻喉科医生临床诊断为鼻炎并通过皮肤点刺试验评估的1,615例患者的病历。评估了鼻炎症状的严重程度，合并症（哮喘，结膜炎和湿疹），变应性疾病的家族病史以及皮肤点刺试验的结果。结果：有392例单敏性鼻炎（mono-sR），325例多敏性鼻炎（poly-sR）和898例非敏化性鼻炎（non-sR）。合并性结膜炎和湿疹在poly-sR中最常见，其次是mono-sR，在非sR患者中最不常见。非sR和单-/ poly-sR的成年患者之间鼻炎发作的年龄明显不同，但单-sR和poly-sR的患者之间没有区别。但是，患有结膜炎或湿疹的非sR和单sR患者的鼻炎发病年龄要比没有合并症的人年轻得多。结论：成人鼻炎患者合并性结膜炎和湿疹的发生频率因免疫球蛋白E致敏的定量特征而异。根据过敏性疾病的多发病率，成人鼻炎患者的鼻炎发病年龄似乎有所不同。
Int Arch过敏免疫