OBJECTIVES The objective of this study was to investigate the relationship between C-reactive protein and procalcitonin and the diagnosis of delirium in critically ill children. DESIGN Retrospective cohort study. SETTING Tertiary care urban academic PICU. PATIENTS All PICU patients (ages 0-21 yr) admitted between January 1, 2015, and December 31, 2017, who had a C-reactive protein and/or procalcitonin level drawn within the first 14 days of their PICU stay. INTERVENTIONS None. MEASUREMENTS AND MAIN RESULTS Each patient was screened for delirium and/or coma bid using the Cornell Assessment of Pediatric Delirium. Patient information including demographics, delirium status, and laboratory values were extracted from the electronic medical record. Seven-hundred thirty-four patients were enrolled, with C-reactive protein and procalcitonin levels drawn in 664 and 587 patients, respectively. Thirty-seven percent of patients (n = 274) were delirious on at least one study day. In bivariate analysis, C-reactive protein was not related to either delirium or coma. Procalcitonin was highest on days with coma and lowest on days with delirium. There was no statistically significant relationship between inflammatory markers and any subtype of delirium. CONCLUSIONS Despite evidence of inflammatory markers being predictive of delirium in adults, in this retrospective pediatric cohort, no association was found between C-reactive protein or procalcitonin levels and development of delirium.

中文翻译：

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C 反应蛋白和降钙素原水平可能无法预测危重儿童的谵妄。

目的 本研究的目的是探讨 C 反应蛋白和降钙素原与危重儿童谵妄诊断之间的关系。设计 回顾性队列研究。设置三级护理城市学术PICU。患者 2015 年 1 月 1 日至 2017 年 12 月 31 日期间入院的所有 PICU 患者（0-21 岁），他们在 PICU 入住的前 14 天内检测了 C 反应蛋白和/或降钙素原水平。干预 无。测量和主要结果 使用康奈尔小儿谵妄评估筛查每位患者的谵妄和/或昏迷。从电子病历中提取患者信息，包括人口统计学、谵妄状态和实验室值。招募了 734 名患者，分别在 664 和 587 名患者中绘制了 C 反应蛋白和降钙素原水平。37% 的患者 (n = 274) 在至少一个研究日出现谵妄。在双变量分析中，C 反应蛋白与谵妄或昏迷无关。降钙素原在昏迷日最高，在谵妄日最低。炎症标志物与任何谵妄亚型之间没有统计学上的显着关系。结论 尽管有证据表明炎症标志物可预测成人谵妄，但在该回顾性儿科队列中，未发现 C 反应蛋白或降钙素原水平与谵妄发展之间存在关联。C反应蛋白与谵妄或昏迷无关。降钙素原在昏迷日最高，在谵妄日最低。炎症标志物与任何谵妄亚型之间没有统计学上的显着关系。结论 尽管有证据表明炎症标志物可预测成人谵妄，但在该回顾性儿科队列中，未发现 C 反应蛋白或降钙素原水平与谵妄发展之间存在关联。C反应蛋白与谵妄或昏迷无关。降钙素原在昏迷日最高，在谵妄日最低。炎症标志物与任何谵妄亚型之间没有统计学上的显着关系。结论 尽管有证据表明炎症标志物可预测成人谵妄，但在该回顾性儿科队列中，未发现 C 反应蛋白或降钙素原水平与谵妄发展之间存在关联。