In this work, the authors reported the hybrid architecture of carbon nanotube (CNT)-zinc oxide (ZnO) nanowire as a multi-functional probe in amperometric immunosensor for the detection of urine albumin. Low-cost substrate such as glass is possible because of novel low-temperature growth process of CNT/ZnO nanowires as a multi-function electrode in this sensor. Based on Schottky like behaviour this structure exhibit excellent high current density to achieve higher performance. Measurement of urine albumin is a new way for early detection of diabetic and also low concentration of it in culture media is also considered in order to verify the conversion of stem cells to liver cells. Human albumin serum antibody is used as a selective and sensitive part. The amperometric performance of immunosensor is studied and showed excellent performance for detection of albumin in urine samples. Very high linear range (from 3.3 ng/µl to 3.3 mg/µl) with a correlation coefficient of 0.825 and low detection limit (3.3 ng/µl or 4.96 × 10-8 mol l-1) are the main characteristics of this sensor. Due to the high dynamic range and sensitivity, this sensor was also used in medical diagnosis and biomedical applications.

中文翻译：

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使用 ZnO 纳米线/碳纳米管混合结构的尿白蛋白高性能免疫传感器。

在这项工作中，作者报道了碳纳米管 (CNT)-氧化锌 (ZnO) 纳米线的混合结构作为多功能探针在安培免疫传感器中用于检测尿白蛋白。由于 CNT/ZnO 纳米线作为该传感器中的多功能电极的新型低温生长工艺，低成本的基板（如玻璃）成为可能。基于类似肖特基的行为，这种结构表现出出色的高电流密度，以实现更高的性能。尿白蛋白的测量是早期发现糖尿病的一种新方法，并且为了验证干细胞向肝细胞的转化，还考虑了培养基中低浓度的白蛋白。人血清白蛋白抗体用作选择性和敏感部分。研究了免疫传感器的安培性能，并在检测尿液样品中的白蛋白方面表现出优异的性能。非常高的线性范围（从 3.3 ng/µl 到 3.3 mg/µl）与 0.825 的相关系数和低检测限（3.3 ng/µl 或 4.96 × 10-8 mol l-1）是该传感器的主要特点。由于高动态范围和灵敏度，该传感器还用于医学诊断和生物医学应用。