An accurate, safe, environmentally friendly, fast and sensitive electrochemical biosensors were developed to detect xanthine in serum. The metal-organic framework ZIF-8 was synthesised and elemental gold was supported on the surface of ZIF-8 by reduction method to synthesise Ag-ZIF-8. The mesoporous carbon material and the synthesised Ag-ZIF-8 were, respectively, applied to a glassy carbon electrode to construct biosensors. The constructed biosensor has a good linear relation in the range of 1-280 μmol l-1 of xanthine and the detection limit is 0.167 μmol l-1. The relative standard deviation value in serum samples was <5%, and the recoveries were 96-106%, indicating the good selectivity, stability and reproducibility of this electrochemical biosensor.

中文翻译：

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用沸石咪唑酯骨架 8 和有序介孔碳检测黄嘌呤的电化学策略。

开发了一种准确、安全、环保、快速、灵敏的电化学生物传感器来检测血清中的黄嘌呤。合成金属有机骨架ZIF-8，通过还原法将元素金负载在ZIF-8表面，合成Ag-ZIF-8。将介孔碳材料和合成的 Ag-ZIF-8 分别应用于玻碳电极构建生物传感器。所构建的生物传感器在黄嘌呤1-280 μmol l-1范围内具有良好的线性关系，检测限为0.167 μmol l-1。血清样品的相对标准偏差值<5%，回收率为96-106%，表明该电化学生物传感器具有良好的选择性、稳定性和重现性。