High Kinetic Energy Ion Mobility Spectrometers (HiKE-IMS) are usually operated at an absolute pressure of 20 mbar reaching high reduced electric field strengths of up to 125 Td for controlled reaction kinetics. This significantly increases the linear range and limits chemical cross sensitivities. Furthermore, HiKE-IMS enables the ionization of compounds normally not detectable in ambient pressure IMS, such as benzene, due to new reaction pathways and the inhibition of clustering reactions. In addition, HiKE-IMS allows the observation of additional orthogonal parameters related to an increased ion temperature such as fragmentation and field-dependent ion mobility, which may help to separate compounds that have similar ion mobility under low field conditions. Aiming for a hand-held HiKE-IMS to carry its benefits into field applications, reducing size and power consumption of the vacuum system is necessary. In this work, we present a novel HiKE-IMS design entirely manufactured from standard printed circuit boards (PCB) and experimentally investigate the analytical performance in dependence of the operating pressure between 20 mbar and 40 mbar. Hereby, the limit of detection (LoD) for benzene in purified, dry air (1.4 ppmV water) improved from 7 ppbV at 20 mbar down to 1.8 ppbV at 40 mbar. Furthermore, adding 0.9 ppmV toluene, the signal of the benzene B+ peak decreased by only 2% at 40 mbar. Even in the presence of high relative humidity in the sample gas above 90% or toluene concentrations of up to 20 ppmV, the LoD for benzene just increased to 9 ppbV at 40 mbar.

中文翻译：

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40毫巴下的高动能离子迁移谱（HiKE-IMS）。

高动能离子迁移谱仪（HiKE-IMS）通常在20 mbar的绝对压力下运行，可达到高达125 Td的高降低电场强度，以控制反应动力学。这显着增加了线性范围，并限制了化学交叉敏感性。此外，由于新的反应途径和对簇反应的抑制，HiKE-IMS能够使通常在环境压力IMS中无法检测到的化合物（例如苯）离子化。此外，HiKE-IMS还可以观察与离子温度升高有关的其他正交参数，例如裂解和与电场有关的离子迁移率，这可能有助于分离在低电场条件下具有相似离子迁移率的化合物。旨在使手持式HiKE-IMS将其优势带入现场应用，减小真空系统的尺寸和功耗是必要的。在这项工作中，我们提出了一种完全由标准印刷电路板（PCB）制造的新颖的HiKE-IMS设计，并根据20 mbar至40 mbar之间的工作压力，通过实验研究了分析性能。因此，纯化的干燥空气（1.4 ppmV的水）中苯的检出限（LoD）从20 mbar时的7 ppbV降至40 mbar时的1.8 ppbV。此外，加入0.9 ppmV的甲苯，苯B +峰的信号在40 mbar时仅下降了2％。即使在样品气体中存在高于90％的高相对湿度或甲苯浓度高达20 ppmV的情况下，苯的LoD在40 mbar时也仅增加至9 ppbV。我们提出了一种完全由标准印刷电路板（PCB）制造的新颖HiKE-IMS设计，并根据20 mbar至40 mbar之间的工作压力，实验研究了分析性能。因此，纯化的干燥空气（1.4 ppmV的水）中苯的检出限（LoD）从20 mbar时的7 ppbV降至40 mbar时的1.8 ppbV。此外，加入0.9 ppmV的甲苯，苯B +峰的信号在40 mbar时仅下降了2％。即使在样品气体中存在高于90％的高相对湿度或甲苯浓度高达20 ppmV的情况下，苯的LoD在40 mbar时也仅增加至9 ppbV。我们提出了一种完全由标准印刷电路板（PCB）制造的新颖HiKE-IMS设计，并根据20 mbar至40 mbar之间的工作压力，实验研究了分析性能。因此，纯化的干燥空气（1.4 ppmV的水）中苯的检出限（LoD）从20 mbar时的7 ppbV降至40 mbar时的1.8 ppbV。此外，加入0.9 ppmV的甲苯，苯B +峰的信号在40 mbar时仅下降了2％。即使在样品气体中存在高于90％的高相对湿度或甲苯浓度高达20 ppmV的情况下，苯的LoD在40 mbar时也仅增加至9 ppbV。净化的干燥空气（1.4 ppmV的水）中苯的检出限（LoD）从20 mbar时的7 ppbV降至40 mbar时的1.8 ppbV。此外，加入0.9 ppmV的甲苯，苯B +峰的信号在40 mbar时仅下降了2％。即使在样品气体中存在高于90％的高相对湿度或甲苯浓度高达20 ppmV的情况下，苯的LoD在40 mbar时也仅增加至9 ppbV。净化的干燥空气（1.4 ppmV的水）中苯的检出限（LoD）从20 mbar时的7 ppbV降至40 mbar时的1.8 ppbV。此外，加入0.9 ppmV的甲苯，苯B +峰的信号在40 mbar时仅下降了2％。即使在样品气体中存在高于90％的高相对湿度或甲苯浓度高达20 ppmV的情况下，苯的LoD在40 mbar时也仅增加至9 ppbV。