Over the last several decades the field has made tremendous progress in understanding the proliferative behavior of cortical progenitors and the lineage relationships of their clonal progeny. The genetic and epigenetic mechanisms that control the dynamic patterns of gene expression during cortical development are only beginning to be characterized. In this review we highlight the most well characterized epigenetic modifications and their influence on progenitor proliferation and cortical neuron cell fate.

中文翻译：

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皮质神经发生的表观遗传调控；在正确的时间和地点安排命运的转变。

在过去的几十年里，该领域在理解皮质祖细胞的增殖行为及其克隆后代的谱系关系方面取得了巨大进展。在皮质发育过程中控制基因表达动态模式的遗传和表观遗传机制才刚刚开始被表征。在这篇综述中，我们重点介绍了最明确的表观遗传修饰及其对祖细胞增殖和皮质神经元细胞命运的影响。