Stimulus-driven gene expression is a ubiquitous feature of biological systems, allowing cells and organisms to adapt their function in a stimulus-driven manner. Neurons exhibit complex and heterogeneous activity-dependent gene expression, but many of the canonical mechanisms that transduce electrical activity into gene regulation are promiscuous and convergent. We discuss literature that describes mechanisms that drive activity-dependent gene expression with a focus on those that allow the nucleus to decode complex stimulus-features into appropriate transcriptional programs.

中文翻译：

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将神经元活动的特征传达给基因组的机制。

刺激驱动的基因表达是生物系统的普遍特征，它允许细胞和生物体以刺激驱动的方式适应其功能。神经元表现出复杂且异质的活动依赖性基因表达，但是将电活动转化为基因调控的许多经典机制是混杂的和会聚的。我们讨论的文献描述了驱动活动相关基因表达的机制，着重于那些允许核将复杂的刺激特征解码为合适的转录程序的机制。