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The Quality of Reporting Raises Questions on the Experimental Validity of Animal Studies Conducted in India and Sri Lanka: Preliminary Analysis of a Systematic Survey
Alternatives to Laboratory Animals ( IF 2.4 ) Pub Date : 2020-03-01 , DOI: 10.1177/0261192920923105
Vijay Pal Singh 1 , Ayushi Jain 1 , Shubhra Gupta 1 , Manudharshy Vijayakumar 2 , Kunal Pratap 1 , Deepanshu Maheshwari 1 , Tharanga Thoradeniya 3
Affiliation  

The quality of animal experiments in terms of appropriate reporting is a concern, particularly with regard to their validity and the recording of the measures taken to reduce various types of bias. A systematic survey of 1371 and 236 publications from India and Sri Lanka, respectively, which were published between 1905 and 2017 and indexed in NCBI-PubMed, Cinhal, MEDLINE and Scopus, was carried out. The level of detail in the descriptions of animals used and the measures taken to reduce bias were analysed in each article. Selected parameters from the Animal Research: Reporting of In Vivo Experiments (ARRIVE) guidelines, such as age, weight, sex, sample size calculation, blinding and randomisation were considered. The findings revealed poor reporting standards in animal experiments carried out in India and Sri Lanka, confirming the limited impact of the ARRIVE guidelines. These findings emphasise the urgent need for improvements in the peer review process, both prior to a study being set up and in the post-study reporting phase, and for more stringent adherence to the ARRIVE guidelines in the reporting of animal experiments.

中文翻译:

报告质量对在印度和斯里兰卡进行的动物研究的实验有效性提出了质疑:系统调查的初步分析

动物实验在适当报告方面的质量是一个问题,特别是在其有效性和为减少各种类型的偏见而采取的措施的记录方面。分别对 1905 年至 2017 年间发表并在 NCBI-PubMed、Cinhal、MEDLINE 和 Scopus 中收录的印度和斯里兰卡的 1371 篇和 236 篇出版物进行了系统调查。每篇文章都分析了所用动物描述的详细程度以及为减少偏差而采取的措施。动物研究:体内实验报告 (ARRIVE) 指南中的选定参数被考虑在内,例如年龄、体重、性别、样本量计算、盲法和随机化。调查结果显示,在印度和斯里兰卡进行的动物实验报告标准很差,确认 ARRIVE 指南的影响有限。这些发现强调迫切需要改进同行评审过程,无论是在研究开始之前还是在研究后报告阶段,以及在动物实验报告中更严格地遵守 ARRIVE 指南。
更新日期:2020-03-01
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