Background: It has been reported that interferon-λ3 (IFNL3)might influence the pathogenesis and clearance of human papillomavirus (HPV) infection. The impact of IFNL3 single-nucleotide polymorphism (SNP) on HPV infection is currently unknown. The aim of this study was to investigate the association between variants in the IFNL3 region and HPV infection in women with human immunodeficiency virus (HIV) infection. Methods: A total of 236 HIV patients, including 65 HPV-negative and 171 HPV DNA-positive women, were enrolled into this study. The IFNL3 rs12979860 polymorphism was genotyped using a predesigned TaqMan SNP genotyping assay. Results: Data showed no significant differences in genotypes or allele frequencies between the HPV DNA-positive and the HPV-negative women (p > 0.05). After dividing the HPV-positive women according to cytology results into patients with abnormal and normal lesions, the genotype and allele distribution of the SNP did not significantly differ between the 2 groups (p > 0.05). Conclusions: Our results showed that the IFNL3 rs12979860 polymorphism is not a major determinant of the susceptibility to HPV infection and their progression to abnormal cervical lesions in women living with HIV.

中文翻译：

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IFNL3 多态性与人乳头瘤病毒感染及其在接受抗逆转录病毒治疗的 HIV 感染女性中的进展之间缺乏关联


背景：据报道，干扰素-λ3（IFNL3）可能影响人乳头瘤病毒（HPV）感染的发病机制和清除。 IFNL3单核苷酸多态性（SNP）对HPV感染的影响目前尚不清楚。本研究的目的是调查人类免疫缺陷病毒 (HIV) 感染女性中 IFNL3 区域的变异与 HPV 感染之间的关联。方法：共有 236 名 HIV 患者纳入本研究，其中 65 名 HPV 阴性和 171 名 HPV DNA 阳性女性。使用预先设计的 TaqMan SNP 基因分型测定法对 IFNL3 rs12979860 多态性进行基因分型。结果：数据显示 HPV DNA 阳性和 HPV 阴性女性之间的基因型或等位基因频率没有显着差异 (p > 0.05)。根据细胞学结果将HPV阳性女性分为异常病变患者和正常病变患者后，两组间SNP的基因型和等位基因分布没有显着差异（p>0.05）。结论：我们的结果表明，IFNL3 rs12979860 多态性并不是 HIV 感染女性对 HPV 感染的易感性及其进展为异常宫颈病变的主要决定因素。